大鼠右室肥厚模型的制作及右心导管法测定大鼠右室压  

A Rat Model of Right Ventricle Hypertrophy

作　　者：鲁亚南[1] 丁文祥[1] 陈恩[1] 蒋祖明[1] 邹文艳[1] 

机构地区：[1]上海第二医科大学附属新华医院上海儿童医学中心小儿心胸外科,上海200127

出　　处：《中国比较医学杂志》2004年第1期31-34,共4页Chinese Journal of Comparative Medicine

摘　　要：目的　探讨大鼠右室肥厚模型的制作及心导管法测定大鼠右室压。方法　将大鼠肺动脉环缩增加其右心室后负荷 ,并经颈外静脉插入自制的右心导管测定右室压力上升的程度。结果　肺动脉环缩 6周后 ,实验组右室游离壁体积及重量均明显增加 ;组织学检查显示明显右室肥厚的病理变化。Objective To evaluate the method of making a right ventricle hypertrophy model in rats and measure rats' right ventricular pressure by catheterization. Method Pulmonary artery banding was performed in male rats of approximately 250g. Right ventricle catheterization was carried out through right external jugular vein in order to monitor the right ventricular pressure and the relationship between this pressure and the degree of banding. Results Right ventricle hypertrophy appeared in all rats by six weeks of banding. The weight of right ventricle free wall was significantly increased(p<0.01). Marked pathological changes of ventricle hypertrophy were observed under light and electron microscope. Conclusion A right ventricle hypertrophy model was successfully created through our methods.

关 键 词：大鼠 右室肥厚模型 右心导管法 大鼠 右室压 肺动脉 

分 类 号：R541[医药卫生—心血管疾病] R-332[医药卫生—内科学]