动脉粥样硬化和胆石症异病同治的实验研究 Ⅰ.益气活血及疏肝理气对家兔动脉粥样硬化的影响  

Experimental Study of Different Diseases (Atherosclerosis and Cholelithiasis) with Same Treatment I.Effects of Yiqi Huoxue and Shugan Liqi agents in Atherosclerosis of Rabbit

作　　者：周群[1] 高明[1] 尹大为[1] 张秀敏[1] 夏素霞[1] 张兢玉 赵冬妮 杜佳林[1] 马杰[1] 李大明[1] 王铁楣[2] 孟凡盛[3] 

机构地区：[1]辽宁省中医研究院病理生理室,沈阳110031 [2]辽宁省中医研究院同位素室,沈阳110031 [3]辽宁省中医研究院生化室,沈阳110031

出　　处：《中国中西医结合杂志》1992年第7期417-420,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(3870538)

摘　　要：本实验比较观察益气活血及疏肝理气两类治则方药对家兔实验性高脂血症及动脉粥样硬化的影响,并从胆汁脂质成份、血浆LPO浓度、环核苷酸及TXA_2-PGI_2水平、血液流变学等指标探讨其机理。结果发现:(1)两类治则方药均有降血胆固醇、改善动脉粥样斑块的作用,且前方优于后方;(2)两类治则方药均能改变胆汁中脂质含量,减少胆石生成,但后方优于前方;(3)改善动脉粥样硬化的机理与降低血脂、降低LPO、提高cAMP/cGMP及改善TXB_2/6-KPGF_(1α)比值有关。实验提示不同方剂可因作用于相同发病环节而起到同病异治的作用。This paper reports the treatment with Yiqi Huoxue and Shugan Liqi agents in atherosclerosis of rabbit. The results suggested: 1. Both decoctions could reduce the cholesterol of hypercholester-olemia and improve the atherosclerosis, but the former was better than the latter. 2. Both decoctions could alter the components of bile lipids, but on the contrary, the latter was better than the former in reducing the formation of gallstones. 3. Both decoctions could decrease the plasma concentration of LPO and ratio of TXB2/6-K-PGF_1α, while increase the ratio of cAMP/cGMP in plasma. So, the different prescriptions of TCM affecting the same link of pathogenesis might play the role of 'Different Treatments in Same Disease'.

关 键 词：动脉粥样硬化 益气活血 胆结石 

分 类 号：R285.5[医药卫生—中药学]