肾病湿热病理的临床分析和实验研究  

Study on Pathogenic Factor(Dampness-Heat)of Glomerulopathy

作　　者：余江毅[1] 熊宁宁[1] 余承惠[1] 龚丽娟[1] 汪君梅[1] 王宁皎[1] 许长照[2] 王维亚 

机构地区：[1]江苏省中医院,南京210029 [2]南京中医学院

出　　处：《中国中西医结合杂志》1992年第8期458-460,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：调查256例原发性肾小球疾病,分析湿热病理与肾功能、水湿、血瘀、正虚诸证及激素的使用、实验室指标等多因素的关系,指出水湿化热是形成湿热病理的重要途径,湿热毒邪是影响肾小球疾病病程的主要病理因素;动物实验提示湿热病理的基础是免疫反应;循环免疫复合物(CIC)及红细胞免疫复合物花环率升高、肾小球系膜增生可作为湿热证的客观指标;湿热与血脂代谢紊乱,血液流变学变化存在较密切关系。清热利湿中药黄蜀葵花可显著改善湿热病变。Mesangial proliferative glomerulonephritis (MsPGN) induced by chronic serum sickness in rabbits coincide with the human chronic progressive glomerulonephritis resulted from repeated infection, which is similar to pathologic changed of Dampness-Heat Syndrome. The experimental model of MsPGN was treated by Abelmoschus manihot which could remove the Dampness-Heat.The amount of proteinuria in treating and control group were 62.68mg/24hr and 121.94mg/24hr respectively (P<05), the number of cells in glomeruli were 61.54 and 80.39 respectively (P<0.01),and diameters of glomeruli were 102.43μm and 121.13μm respectively (P<0.01). It suggested that the drug could alleviate circulating immune complex (CIC) mediated renal injury.

关 键 词：湿热病理 红细胞 肾小球疾病 

分 类 号：R256.502[医药卫生—中医内科学]