成年大鼠全臂丛根性撕脱伤后对侧运动皮层可塑性变化的实验研究  

Experimental study on changes of plasticity of contralateral motor cortex follow ing total brachial plexus root avulsion injuries in the adult rats

作　　者：李占玉[1] 徐文东[1] 徐建光[1] 顾玉东[1] 

机构地区：[1]复旦大学华山医院手外科,上海200040

出　　处：《中华手外科杂志》2004年第1期51-54,共4页Chinese Journal of Hand Surgery

基　　金：国家自然科学基金资助项目(30200288);复旦大学研究生创新基金资助项目(QF151802);国家 973创伤基础研究基金资助项目(G1 9990 542 0 2 )

摘　　要：目的　探讨成年大鼠全臂丛根性撕脱伤后不同时间段对侧运动皮层的可塑性变化。方法　将 3 0只SD雄性大鼠分为 6组 ,即正常对照组和全臂丛根性撕脱伤术后 1d、7d、1个月、3个月、1年共 5个时间组 ,每组 5只。采用皮层内微电极电刺激技术 ,定量评价大鼠左前肢代表区内的可塑性变化。结果　术后不同时间组在原前肢代表区内可诱发出不同的运动类型 ,包括左侧胡须、下颌、颈部和左下肢 4个部位点的运动 ,但只有颈部位点自始至终占据着术前前肢代表区。结论　成年大鼠的运动皮层仍具有可塑性 ,术后对侧运动皮层在术前前肢代表区发生了功能重组 ,并且这种功能重组是动态变化的。ObjectiveTo investigate changes of plasticity of contralateral mo tor cortex at different intervals following total brachial plexus root avulsion injuries in adult rats. MethodsTotal left brachial plexus root avulsion injury model was set up in 25 male Sprague-Dawley rats. They were divided into 5 gro u ps according to different intervals of examination, including 1 day, 7 days, 1 m onth, 3 months and 1 year groups. Another 5 rats without surgery served as the normal control group. Intracortical microstimulation was used to quantitatively evaluate the changes of plasticity of the corresponding left forelimb motor regi on. ResultsVarious types of movement were evoked in the left f orelimb represe ntation region throughout the entire period after the innervating nerves were di sconnected. However, the sites of neck firmly occupied the left forelimb represe ntation region throughout the entire process.ConclusionThe mot or cortex of a dult rats still had the ability of plasticity. Dynamic functional reorganization took place in the forelimb representation region of the contralateral primary m otor cortex following disconnection of the brachial plexus. The control strength of the muscles above the paralyzed muscles was significantly enhanced in compen sation.

关 键 词：成年大鼠 全臂丛根性撕脱伤 运动皮层可塑性 实验 脑功能重组 

分 类 号：R651.3[医药卫生—外科学]