正常人腰段脊柱结构内nNOS阳性神经末梢的分布  

Distribution of nNOS-positive nerve endings in relative structures of human lumbar spinal column

作　　者：王劼[1] 刘才栋[1] 沈馨亚[1] 彭裕文[1] 

机构地区：[1]复旦大学上海医学院解剖与组织胚胎学系,上海200032

出　　处：《解剖学研究》2003年第4期293-294,299,I005,共4页Anatomy Research

摘　　要：目的　观察正常人腰段脊柱结构内nNOS阳性神经末梢的分布 ,探讨下腰痛的发病机制。方法　用免疫组化方法观察 3例人腰段脊柱结构内nNOS阳性神经末梢存在情况。结果　人腰椎关节突关节囊的纤维层、黄韧带、棘间韧带、棘上韧带和椎间盘的纤维环内均有nNOS免疫反应阳性神经末梢存在 ,这些神经末梢呈树枝状或念珠状 ,其走行与结缔组织纤维方向一致。结论　NO参与了人腰椎关节突关节囊、黄韧带、棘间韧带、棘上韧带和椎间盘的纤维环等结构的感觉信息的传递。人脊柱相关结构的神经末梢受刺激时 ,促使NO的释放和传递可能是引起原发性腰痛的原因之一。Objective In order to understand the pathogenesis of low back pain. Methods Nerve endings of nNOS positive in relative structures of human spinal column were viewed by immunohistochemistry in 3 cases human body. Results The main results were showed as follows: There were nNOS positive nerve endings in fibrous coat of capsule of lumbar zygapophyseal joints, flava ligament, interspinalia ligament, supraspinale ligament and annulus fibrous of intervertebrale disc. These nerve endings present arborization or beads, the direction of these nerve endings according to connective fibers. Conclusions The summarizing conclusions showed NO take part in transmission of sensation message among capsule of lumbar zygapophyseal joints, flava ligament, interspinalia ligament, supraspinale ligament and annulus fibrous of intervertebrale disc. When stimulating the nerve endings in the constitution of human spinal column, impelling the nerve endings to liberate and transmit of NO, it maybe one of reasons which caused primary low back pain.

关 键 词：下腰痛 神经元型一氧化氮合酶 发病机制 免疫组化法 脊柱结构 神经末梢 炎症介质 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]