急性泛发性发疹性脓疱性皮病12例临床病理分析  

Clinicopathological analysis of 12 cases of acute generalized exanthematous pustulosis

作　　者：徐秀莲[1] 孙建方[1] 姜祎群[1] 曾学思[1] 崔盘根[1] 贾虹[1] 杨雪源[1] 李和莲[1] 刘维达[1] 

机构地区：[1]中国医学科学院,中国协和医科大学皮肤病研究所,江苏南京210042

出　　处：《临床皮肤科杂志》2004年第2期89-91,共3页Journal of Clinical Dermatology

摘　　要：目的了解急性泛发性发疹性脓疱性皮病AGEP的发病原因、临床病理特征及治疗情况。方法回顾性分析12例AGEP患者的临床资料。结果12例患者中2例有银屑病病史。男女发病之比为1∶3,平均发病年龄31.3岁。7例患者发病前有明确的用药史,4例有病毒或细菌感染史,11例患者有发热及白细胞和嗜中性粒细胞增多。AGEP病程短暂且有自限性。组织病理学检查示表皮内或角质层下脓疱和真皮浅层水肿。去除可能的发病因素药物和清除感染灶,给予中、小剂量的糖皮质激素口服或注射,患者基本痊愈。结论AGEP为一种较少见的疾病,多由药物引起,临床及病理上具有特征性,去除诱发因素和及时应用糖皮质激素是治疗的关键。Objective: To explore the etiology, clinical and histological features and treatment in patients with acute generalized exanthematous pustulosis (AGEP). Methods: Twelve cases of acute generalized exanthematous pustulosis were analyzed retrospectively. Results: Two of these cases were occurred in patients with a history of psoriasis, the ratio of female to male was 3 to 1. The average age was 31.3 years old. Seven cases were drug-induced. four cases were followed virus or bacterial infection. Eleven cases had fever , leukocytosis and neutrophilia. Histopathological examination revealed spongiform superficial pustules and papillary edema. The precipitating factors ( the suspected drug and infection focus) were kept off and low-medium doses of steroids was administered, almost all patients were healed. Conclusion: AGEP is a rare but distinctive entity with the clincal and histopathological features.

关 键 词：脓疱性皮病 发疹性 急性泛发性 临床病理特征 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]