咪唑啉受体激动剂莫索尼定对家兔希氏束电位的影响  

The effect of imidazoline receptor agonist-moxonidine on the His bundle electrogram in vivo

作　　者：齐颖新[1] 牛小麟[1] 谢松梅[1] 苟伟[2] 杨银京[2] 

机构地区：[1]西安交通大学第二医院心血管内科,陕西西安710004 [2]西安交通大学医学院机能中心,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2004年第2期132-134,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的　观察咪唑啉受体激动剂 莫索尼定 (Mox)对家兔在体心脏希氏束电位的影响。方法　将 2 4只健康家兔随机分为 4组 :空白对照组 ;Mox小剂量组 (0 .1mg·kg-1) ;Mox中剂量组 (0 .3mg·kg-1) ;Mox大剂量组(0 .9mg·kg-1) ,采用经右侧颈总动脉插管法 ,记录希氏束电图 (HBE) ,同步测量体表心电图 (ECG)。结果　静脉注射Mox后 ,家兔ECG的R R间期、P R间期和HBE的H V间期较空白对照组明显延长 ,且呈剂量依赖性关系 ,给药前、后HBE的A H间期与空白对照组相比无明显差异。结论　静脉注射Mox能剂量依赖性延长家兔HBE的H V间期 ,而对A H间期无明显作用 。Objective To study the effect of moxonidine (Mox) on the His bundle electrogram (HBE) of normal rabbits. Methods A total of 24 healthy rabbits were randomly divided into four groups: control group, small dose of Mox (0.1 mg·kg -1), medium dose of Mox (0.3 mg·kg -1) and large dose of Mox (0.9 mg·kg -1). The electrode catheter was inserted from the right carotid artery to record the HBE. The HBE and the synchronism surface ECG were recorded before and after intravenous injection. Results In normal rabbits, the R-R interphase, P-R interphase of the ECG and the H-V interphase of the HBE were prolonged in a dose-dependent manner after intravenous injection of Mox. Mox exerted no significant influence on the A-H interphase. Conclusion ① Mox decreases the heart rate of rabbits in a dose-dependent manner in vivo. ② Mox dose-dependently prolongs the P-R interphase of the surface ECG and the H-V interphase of HBE. This indicates that Mox mainly acts on the intraventricular conducting system.

关 键 词：咪唑啉受体激动剂 莫索尼定 家兔 希氏束电位 降压药 心脏传导 心律失常 

分 类 号：R972.4[医药卫生—药品] R541[医药卫生—药学]