^(99m)Tc-HL91心肌乏氧组织显像的初步实验研究  

A preliminary experimental study on myocardial hypoxia imaging using ^(99m)Tc-HL91

作　　者：侯妮[1] 李杰[2] 邹保民[3] 胡国瑛[3] 邓惠兴[3] 

机构地区：[1]西安交通大学医学院核医学教研室,陕西西安710061 [2]武警陕西总队医院外一科,陕西西安710054 [3]西安交通大学第一医院核医学科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2004年第2期192-194,共3页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的　验证乏氧组织显像剂99mTc HL91能选择性浓集于缺血的心肌中 ,为临床显像提供依据。方法　制备兔心肌缺血模型 ,观察99mTc HL91在缺血心肌中的分布情况。按常规方法观察99mTc HL91在正常兔体内的分布情况。结果　电生理改变及NBT染色均证实兔左心室LCX区心肌缺血。左心室切片显像见LCX区心肌较LAD区放射性明显增浓。LCX/LAD组织放射性比 :12 0min ,2 .5 7;180min ,3.4 5。99mTc HL91主要分布在肝脏和肾脏 ,其次为胃肠道 ,排泄以泌尿系、肠道为主 ,正常心肌及肺脏中分布少 ,且清除较快。血液清除快。结论　缺血心肌组织较正常组织滞留99mTc HL91明显增高 ,180min时较显著。提示99mTcObjective To certify whether 99mTc-HL91 can be trapped in ischemic myocardium prominently for clinical imaging. Methods The model of myocardial ischemia in rabbits was prepared and the distribution of 99mTc-HL91 was observed. The distribution of 99mTc-HL91 in the whole body was also observed. Results The myocardium of the left ventricle supplied by LCX was ischemic according to the change of electrical physiology and the results of NBT dying. The radioactivity in the myocardium of left ventricle supplied by LCX was higher than that supplied by LAD. LCX/LAD: 120 min, 2.57; 180 min, 3.45. 99mTc-HL91 was mostly distributed in the liver and kidney, next, the stomach and intestine. It was excreted through urination and defecation. There was little radioactivity in the heart and lungs and it eliminated quickly. 99mTc-HL91 was eliminated quickly from blood, too. Conclusion Ischemic myocardium can trap 99mTc-HL91 more significantly and relatively prominently at 180 minutes of post-injection. 99mTc-HL91 can be used in myocardial hypoxia imaging.

关 键 词：^99MTC-HL91 实验 心肌缺血 心肌组织乏氧 显像剂 放射诊断 

分 类 号：R542.2[医药卫生—心血管疾病] R816.2[医药卫生—内科学]