慢性肺心病血乳酸及丙酮酸含量研究  

Serum lactate and pyruvate levels in patients with cor pulmonale

作　　者：张新日[1] 王予思[2] 杜永成[2] 许建英[2] 张晓云[2] 刘瑶华[2] 

机构地区：[1]华中科技大学同济医学院附属同济医院呼吸科,武汉430022 [2]山西医科大学第一临床医学院呼吸科

出　　处：《山西医科大学学报》2004年第2期136-137,共2页Journal of Shanxi Medical University

摘　　要：目的　探讨肺心病患者血乳酸及丙酮酸含量及其影响因素。方法　同步测定 112例慢性肺心病患者和 74例健康献血员血清乳酸及丙酮酸含量。结果　健康献血员各年龄组血乳酸 (L)、丙酮酸 (P)及L/P比值间差异均无显著性 (P >0 .0 5 ) ,112例慢性肺心病患者中发生高乳酸血症者有 73例次 ,发生乳酸酸中毒者有 2 1例次。相关性检验分析结果表明 ,PO2 与L之间无明显相关 ,PO2 与L/P之间呈负相关 ,L与 [H+ ]之间呈正相关。结论　年龄对健康人血乳酸和丙酮酸含量无明显影响 ;血乳酸含量只能反映组织的酸中毒程度 ,不能反映组织的缺氧程度 。Objective To investigate the serum lactateand pyruvate contents and affecting factors in 112 patients with cor pulmonale. Methods Serum lactate and pyruvate in 112 cases of cor pulmonale and 74 cases of health blood donor were measured simultaneously. Results No evident difference existed in serum lactate, pyruvate and L/P ratio among all ages of health blood donor(P>0.05). Seventy-three cases of hyperlactaemia and 21 cases of lactic acidosis were found in 112 cases of cor pulmonale. Relativity study showed that no evident relativity existed between PO 2 and L, butthat negative relativity between PO 2 and L/P ratio and positive relativity between L and . Conclusion Age has no obvious effects on serum lactate and pyruvate content. The blood lactate content can not reflectthe acidosis extent of tissues. The increased L/P ratio is of certain relationship to hypoxia.

关 键 词：慢性肺心病 血乳酸 丙酮酸 组织缺氧 影响因素 

分 类 号：R541.5[医药卫生—心血管疾病]