吲哚美辛酶解型结肠靶向片的初步研究  

Indomethacin Enzyme-controlled Tablets for Colon-targeting Drug Delivery

作　　者：曹健[1] 董雅琴[1] 陆锦芳[1] 

机构地区：[1]复旦大学药学院药剂教研室,上海200032

出　　处：《中国医药工业杂志》2004年第4期213-215,共3页Chinese Journal of Pharmaceuticals

摘　　要：采用湿法制粒压片制备吲哚美辛瓜尔胶骨架片,并测定了模拟人体胃肠道生理环境下的体外释放度。结果表明,骨架片5h内释药不超过20%;26h内不加酶组的总释药量不超过40%,加酶组为88%左右,能达到结肠靶向给药的效果。Indomethacin guar gum(GG) tablets were prepared by wet granulation technique. The drug releasebehavior from the matrix tablets were evaluated under the following conditions : 2h in 0.1 mol/L HCl and then 3h in pH7.4phosphate buffer solution(PBS), followed by 21h in pH6.8 PBS with or without galactomannanase. Less than 20% ofindomethacin was released in the first 5h.More than 88% of drug release was observed in the medium with enzymecompared to only 40% in the absence of galactomannanase after 26h. The results showed that GG used as tablet matrix wasa potential carrier for drug targeting to colon.

关 键 词：吲哚美辛 瓜尔胶 结肠靶向 酶解型 骨架片 

分 类 号：R944.4[医药卫生—药剂学] R971[医药卫生—药学] .1