结肠创伤性腹内感染的实验研究  

An Experimental Study of Intraperitoneal Infection from Colonic Trauma

作　　者：王来根[1] 王元和[1] 徐宪虎[1] 高瀚[1] 王岚[2] 朱诚[1] 张鸿祺[1] 孔宪涛[3] 马妙发[1] 王炳森 陈学云[1] 胡志前[1] 

机构地区：[1]第二军医大学长征医院普外科 [2]第二军医大学长征医院病理科 [3]第二军医大学长征医院实验诊断中心 [4]上海职防所电镜室

出　　处：《中华创伤杂志》1992年第6期360-362,共3页Chinese Journal of Trauma

基　　金：全军"七五"协作攻关资助课题

摘　　要：创伤与感染尤其是肠源性感染关系密切。本实验采用大鼠盲肠穿孔模型,胃管导入大肠杆菌,进行血浆内毒素测定;~3H标记菌示踪及组织形态学光、电镜等观察。结果表明:肠穿孔后腹内感染是明确存在的,并由此继发了广泛性肠道屏障损害致肠腔内菌群和内毒素的全身性播散及多脏器的损害,其程度与肠穿孔大小及病程呈一致性相关,这不但是结肠源性腹内及全身感染发生和发展的共同发病途径,也是脓毒败血症、顽固性休克以及MSOF的主要潜在根源。充分认识这一病理征象,对指导本症的早期防治具有重要意义。There is a close relation between trauma and infection, especially gut origin septic states. A model of cecum perforation of rats was used in this experiment. We tube-fed ~3H Coli to rats, and observed serum endotoxin level, ~3H labled Coli trace, cellular and subeellular structures. The results showed that after perforation of cecum, the intraperitoneal infection existed definitely, and induced the injury of the numerous barriers of intestinal mucosa, leading to spreading the intestinal flore and endotoxin to all system and injury of multiple organs. There was a positive correlation between the severity and diameter and the time of cecum perforation. The injury of the numerous barriers of intestinal mueosa is. not only a common way to involving in occurrence and growth of intraperitoneal and systemic infection from colon, but also a main latent origin of sepsis, irreversible shock and MSOF. Therefore understanding fully this pathological sign and objective fact plays an important role in early prevention and treatment for this disease.

关 键 词：肠源性感染 肠粘膜屏障 结肠损伤 

分 类 号：R63[医药卫生—外科学]