长效涂肤剂“防蚴灵”预防血吸虫尾蚴感染的研究  

STUDIES ON LONG-EFFECTIVE VARNISH “FANGYOULING”IN PREVENTION OF SCHISTOSOMA CERCARIA INFECTION

作　　者：严晓岚[1] 杨明瑾[1] 漏磊君[1] 吴玲娟[1] 李思温[1] 

机构地区：[1]浙江省医学科学院寄生虫病研究所,杭州310013

出　　处：《中国血吸虫病防治杂志》2003年第2期135-138,共4页Chinese Journal of Schistosomiasis Control

基　　金：卫生部世界银行贷款血吸虫病控制项目联合科研管理委员会 ( JRMC)资助 ( J2 -10 )

摘　　要：目的　观察“防蚴灵”涂肤剂预防血吸虫尾蚴感染的效果。方法　用氯硝柳胺加透皮促进剂制成 1% - 2 %浓度的“防蚴灵”,对感染前 1、2、3、4、5、6、7d涂肤的小白鼠和家兔分别进行预防血吸虫尾蚴感染的试验 ,并与对照组比较。结果　小鼠在感染前 1- 4 d,涂 1%防蚴灵 1次 ,其减虫率为 10 0 % ,在感染前 5 - 7d涂药 1次 ,减虫率为 99.7% - 88.1%。家兔感染前 3- 7d涂 2 %的防蚴灵1次 ,减虫率为 86 .4 % - 80 .1%。结论　涂肤剂“防蚴灵”ObjectiveTo observe the effe ct of varnish“Fangyouling” preventing skin invasion from Schist osoma cercariae. MethodsThe“Fangyouling” was made from niclo s amide and permeable improver, and the concentration of the drug was 1%-2%. Exper imenta l mice and rabbits were spread with “Fangyouling” on the abdomen skin without h air at day 1,2,3,4,5,6,7 respectively before infection, compaired with cont rol group. ResultsThe worm reduction rates of mice which were spread with drug 1-4 days and 5-7 days before infection were 100 % and 99 7%-88 1%. The worm reduction rates of rabbits which were spread with dr ug 3-7 days before infection were 86 4%-80 1%. ConclusionThe“Fangyouling” has long efficiency on preventing Schistosoma cercariae from invading skin.

关 键 词：防蚴灵 氯硝柳胺 血吸虫尾蚴 

分 类 号：R383.24[医药卫生—医学寄生虫学]