Effects of PVP K30 on Aqueous Solubility and Dissolution Propertiesof Daidzein  

PVP K30对葛根黄豆苷元溶解度和溶出的影响(英文)

作　　者：郭圣荣[1] 郭丽[1] 

机构地区：[1]上海交通大学药学院,上海200030

出　　处：《Journal of Chinese Pharmaceutical Sciences》2004年第1期42-48,共7页中国药学（英文版）

摘　　要：AimTo study effects of PVP K30 on the aque ou s solubility and dissolution properties of daidzein. Methods To measure the aqueous solubility and dissolution rates of daidzein in three diffe rent states (within solid dispersions, physical mixtures and as a pure drug) and investigate drug-polymer interactions in the solid state using X-ray powder d iffraction and fourier-transform infrared spectroscopy. Results The negative values of the Gibbs free energy and enthalpy of transfer explaine d the spontaneous transfer of daidzein from phosphate buffer solution (PBS) to a solution of PVP in PBS. X-ray powder diffraction patterns showed that the drug was in the amorphous state (ratio of the drug ∶ PVP<1∶5) when dispers ed i n PVP K30. The infrared spectra indicated there exist interactions between the O H of daidzein and the C=O of PVP K30. Conclusionthe dispersion of daidzein in PVP K30 considerably enhances the solubility and dissolution rat e.目的研究PVPK3 0对葛根黄豆苷元水溶解性和溶出性质的影响。方法　测量葛根黄豆苷元及其固体分散体、物理混合物的水溶解度和溶出速度 ,并用X -射线衍射、IR表征药物与PVP在固态条件下的相互作用。结果　Gibbs自由能和转移焓均小于零 ,表明葛根黄豆苷元从磷酸盐缓冲溶液中转移到PVP的磷酸盐缓冲溶液中是一自发的过程 ;X -射线衍射结果表明葛根黄豆苷元在PVP固体分散体 (药物∶PVP <1∶5)中以无定形形式存在 ;IR结果表明葛根黄豆苷元的羟基与PVP分子中的C =O之间存在相互作用。

关 键 词：DAIDZEIN PVP K30 SOLUBILITY solid dispersion s X-ray powder diffraction infrared spectroscopy 

分 类 号：R284[医药卫生—中药学]