一氧化碳抑制剂治疗感染性休克的实验研究  

An experimental study on the effects of carbon monoxide inhibitor in septic shock

作　　者：覃世文[1] 史源[1] 李华强[1] 潘捷[1] 蒋东波[1] 沈际皋[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所儿科,重庆400042

出　　处：《重庆医学》2004年第4期514-515,共2页Chongqing medicine

摘　　要：目的　由血红素氧合酶 (HO)催化血红素分解代谢而形成的一氧化碳 (CO)可能作为一种新的内源性介质参与感染性休克一系列病理生理过程。方法　本文应用实验家兔注射内毒素所致感染性休克模型 ,观察CO在感染性休克病程中的变化以及HO抑制剂锌原卟啉的疗效。结果　血浆CO水平于内毒素注射后迅速增高 ,应用HO抑制剂锌原卟啉能显著抑制血浆CO水平的增高 ,并可显著减轻内毒素所致的血压降低和代谢性酸中毒程度。结论　HO抑制剂治疗感染性休克的临床价值值得深入研究。Objective Endogenous carbon monoxide (CO),which was mainly produced through the metabolism of heme catalysed by hemeoxygenase (HO),was suggested to play a role in the pathophysiology of septic shock.Methods A rabbit model of septic shock conducted by entotoxin administration was used to investigate the changes of CO and the effects of HO inhibitors in septic shock.Results Plasma CO levels of rabbit model of septic shock increased rapidly after endotoxin administration,HO inhibitor zinc protopropyrin reduced the enhancement of plasma CO levels,the hypotension and metabolic acidosis caused by endotoxin administration.Conclusion Our results suggests that the value of HO inhibitor in septic shock treatment should be studied further.

关 键 词：一氧化碳 休克 感染性 血红素氧合酶 

分 类 号：R965[医药卫生—药理学]