高甘油三酯血症对血管内皮功能的影响(英文)  

The Effect of Hypertriglyceridemia on Vascular Endothelial Function

作　　者：黄芸[1] 戴闺柱[1] 冯宗忱[2] 鲁成发[3] 成蓓[1] 王秋芬[1] 聂福鼎[1] 李景东[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院心内科,湖北武汉430022 [2]华中科技大学同济医学院生化教研室 [3]华中科技大学同济医学院附属协和医院超声科

出　　处：《高血压杂志》2004年第2期120-122,共3页Chinese Journal of Hypertension

摘　　要：目的　观察高甘油三酯血症对血管内皮功能的影响。方法　对 30例高甘油三酯血症患者和 30例正常人 ,采用高分辨超声技术检测血流介导的和硝酸甘油介导的肱动脉舒张功能 ,并测定血浆内皮素和血脂。结果　 1.高甘油三酯血症组血流介导的肱动脉舒张较正常组明显减弱 [分别为 (2 7± 2 0 ) %和 (15 0± 8 0 ) % ,P <0 0 0 1],而两组对硝酸甘油的血管舒张反应无显著性差异 [分别为 (15 0± 5 0 ) %和 (16 8± 9 0 ) % ,P >0 0 5 ]。 2 高甘油三酯血症组血浆内皮素水平显著高于正常组 [分别为 (10 6 2 2± 19 16 ) μg/L和 (72 37± 14 0 6 ) μg/L ,P <0 0 0 1]。结论　高甘油三酯血症患者内皮依赖性血管舒张功能明显受损。血管内皮功能失调可能是高甘油三酯血症致动脉粥样硬化的一个重要机制。Objective To investigate the effect of hypertriglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow and nitroglycerin-induced dilatation of the brachial artery were determined in thirty hypertriglyceridemic patients and thirty healthy subjects as controls. Serum lipid and plasma endothelin (ET) were determined. Results In patients with hypertriglyceridemia, flow-induced vasodilatation was much reduced compared with that in the control subjects [(2.7±2.0)% vs (15.0±8.0)%, P<0.001]. However, vasodilatation in response to nitroglycerin were similar in both groups [(15.0±5.0)% vs (16.8±9.0)%, P>0.05]. Plasma ET level in the hypertriglyceridemic group was significantly higher than that in the control group [(106.22±19.16) μg/L vs (72.37±14.06) μg/L, P<0.001]. Conclusion Endothelium-dependent vasodilatation was impaired in patients with hypertriglyceridemia.

关 键 词：高甘油三酯血症 内皮 血管舒张 

分 类 号：R589.2[医药卫生—内分泌] R543.5[医药卫生—内科学]