伊贝沙坦与苯那普利对高血压病的左室肥厚逆转作用  

Effect of irbesartan combined with benazapril on rever sing left ventricular hypertrophy in patients with essential hypertension

作　　者：谢秀成[1] 刘明[1] 黄仕洲[1] 

机构地区：[1]广东肇庆市第一人民医院心内科,526021

出　　处：《中国基层医药》2004年第1期8-9,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的　探讨伊贝沙坦、苯那普利联合用药对原发性高血压 (EH)病人左室肥厚 (LVH )的逆转作用。方法　EH伴有LVH病人 112例随机分为A组 (伊贝沙坦 150mg/d ,3 8例 )、B组 (苯那普利 10mg/d ,3 7例 )和C组 (伊贝沙坦 150mg/d ,加苯那普利 10mg/d ,3 7例 )。治疗 3周时若血压≥ 160 / 95mmHg ,则伊贝沙坦和苯那普利剂量分别增加 1倍。总疗程共 6个月 ,治疗前后 2 4h动态血压监测和彩色超声多普勒检测左室相关指标 ,计算左室重量指数 (LVMI)。结果　①三组均能显著降低LVMI(P <0 0 1) ,其中A组和B组LVMI的降低差异无显著意义 (P >0 0 5) ,C组LVMI降低较A组、B组更为显著 ,差异有显著意义 (P <0 0 1)。②三组治疗前 2 4h平均收缩压、平均舒张压差异无显著意义 (P >0 0 5) ,治疗后 2 4h平均收缩压、平均舒张压均较治疗前显著降低 (P <0 0 1) ,但治疗后三组间比较均无明显差异 (P >0 0 5)。结论　伊贝沙坦、苯那普利均能逆转EH病人LVH ,联合用药疗效更为显著 。Objective To study the effect s of irbesartan and benazapril used individually or in combination on reversing le ft ventricular hypertrophy(LVH) in patient with essential hypertension(EH).Methods A total of 112 patients with EH were divided randomly into t hree groups:irbesartan group(150mg qd,n=38),benazapril group(10 mg qd,n=37) and combined treatment group(irbesartan 150mg qd+b enazapril 10mg qd,n=37).If the blood pressure(BP)≥160/95mmHg w as remained after 3 weeks treatment,then the dosees doubled.Treatment lasted for 6 months.LVMI was measured by heart Doppler ultrasound before and after treatme nt.The blood pressure was recordedby ABPM at same time.Results (1)After 6 months,LVMI was significantly less than that before treatment in the three groups(P<0.01).LVMI in the combined treatment group was l ess than that in the irbesartan and benazapril groups(P<0.01).N o significant difference was found between irbesartan and benazapril groups(P>0.05).(2)Before treatment,24h SBP and 24h DBP did not show signif icant difference respectively in the groups(P>0.05).After 6 mon ths,24h SBP and 24h DBP decreased more obviously than those before treatment(P<0.01),but did not show difference between the three groups(P>0.05).Conclusion Irbesartan combined with benazap ril has additive effect on reversing LVH in patients with EH,and this additive e ffect do not associate with decreasing blood pressure.

关 键 词：伊贝沙坦 苯那普利 高血压病 左室肥厚 药物治疗 联合用药 

分 类 号：R541.3[医药卫生—心血管疾病]