孕期乙肝病毒宫内感染的临床观察  

The Clinical Observation of Intrauterine Infection of HBV during Pregnancy

作　　者：张平[1] 朱理珉[1] 张玉荣[1] 李伟[1] 陈静[1] 郝金玉[1] 

机构地区：[1]天津市传染病医院,300192

出　　处：《天津医药》2004年第4期217-218,共2页Tianjin Medical Journal

摘　　要：目的 :探讨乙型肝炎病毒在生殖生育过程中传播给下一代的途径及相关因素和阻断方法。方法 :对498例乙肝病毒表面抗原阳性的产妇所产新生儿于生后即刻取股静脉血 ,检测其乙肝病毒标志物和HBV -DNA ,并根据孕产妇HBV -DNA检测结果分为阳性和阴性组 ,再根据孕妇产前使用乙肝免疫球蛋白(HBIG)情况分组观察使用效果。结果 :283例HBV -DNA阳性组新生儿宫内感染率为39.6 % ;215例HBV -DNA阴性组为13.5 %。两组比较差别有统计学意义。孕期是否使用HBIG两组宫内感染率差别无统计学意义。结论 :宫内感染与孕妇HBV_DNA是否阳性有关 。Objective:To explore the spread pathway, relative factors, and treatment of HBV intrauterine infection of HBV during pregnancy.Methods:Serous HBV -markers and HBV-DNA were detected in 498 newborns whose mothers' HBsAg were positive. According to the results of HBV-DNA and the use of HBIG, the pregnant women were divided into 4 groups.Results:The intrauterine infection of HBV was 39.6%in 283 pregnant women with HBV-DNA positive, and 13.5%in 215 pregnant women with HBV-DNA negative. There was a significant difference between two groups. There was no correlation in the use of HBIG. Conclusion: The intrauterine infection is relative to HBV-DNA positive.There is no effect with the use of HBIG to prevent HBV infection during pregnancy.

关 键 词：孕期 乙肝病毒 宫内感染 临床观察 

分 类 号：R714.251[医药卫生—妇产科学]