蛇纹石降氟前后的砖茶水对小鼠微核率的影响  

Effects of brick tea liquor on micronucleus rate of mouse before and after defluoridation with Serpentine

作　　者：冯红旗[1] 庞永珣[1] 石玉霞[1] 孙殿军[1] 

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心地氟病防治研究所,黑龙江哈尔滨150086

出　　处：《中国地方病学杂志》2003年第4期318-319,共2页Chinese Jouranl of Endemiology

基　　金：黑龙江省科技攻关项目 ( GB0 2 C1 1 4)

摘　　要：目的　探讨蛇纹石降氟前后砖茶水对小鼠骨髓嗜多染红细胞微核率的影响。方法　用活化的蛇纹石除去砖茶水 (氟浓度为 3 .0 mg/L)中的氟至 1.0 mg/L。将降氟前后的砖茶水各分高、中、低 3个剂量组进行灌胃 ,阴性对照组和阳性对照组分别用生理盐水灌胃和环磷酰胺腹腔注射。比较各实验组及阳性对照组与阴性对照组的微核率。结果　蛇纹石降氟前及降氟后各砖茶水组微核率与对照组相比差别均无显著性 (P >0 .0 5)。结论　无论降氟前降氟后 ,砖茶水都未引起小鼠骨髓嗜多染红细胞微核率升高 。Objective To study the effects of brick tea l iquor before and after defluoridation by serpentine on micronucleus rate in mice .Methods The level of fluoride in brick tea liquor was reduced from 3.0 mg/L to 1.0 mg/L, then mice were injected according to low, middle and high fluoride dosage with brick tea liquor before and after defluori dation by serpentine, respectively. The micronucleus rates of polychromatic eryt hrocyte in mouse marrow of different groups were determined.Results The micronucleus rates of the brick tea liquor before and after defluoridation by serpentine were higher than those of control group. However, the difference was not significant (P>0.05).Conclusions The brick tea liquor before and after deflu oridation by serpentine cannot give rise to micronucleus rate of mice. So the b rick tea liquor before and after defluoridation by serpentine cannot bring obvio us damage to the chromosome of mice.

关 键 词：蛇纹石 降氟作用 砖茶水 小鼠 微核率 染色体 

分 类 号：R114[医药卫生—卫生毒理学]