组织细胞坏死性淋巴结炎的病毒学免疫表型  

A virologic immunophenotypic study on histiocytic necrotizing lymphadenitis

作　　者：肖家诚[1] 金晓龙[1] 陆建波[1] 

机构地区：[1]上海第二医科大学附属瑞金医院病理科,上海200025

出　　处：《临床与实验病理学杂志》2003年第5期496-499,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的　研究组织细胞坏死性淋巴结炎 (或称Kikuchi病 ,KD)可能致病的病毒因素。方法　对 30例KD存档蜡块做HE和免疫组化染色 ,观察其病毒感染的可能性。另取 5例非特异性淋巴结炎 (NLD)作为阴性对照。结果　KD及NLD组织内HBsAg均阴性。HPV在KD和NLD中均有高表达 (6 6 7%和 6 0 % ) ,HSV 2也在部分KD(4 0 % )和NLD病人 (2 0 % )出现阳性。此外 ,有 36 6 % (1 1 / 30 )的KD病人EB病毒阳性 ,而NLD淋巴结内EB病毒阴性。结论　HBsAg、HPV和HSV 2可能不是KD的致病因子。EB病毒在KD感染率较高 ,而在NLD阴性 ,其相关性有待进一步探讨。Purpose To study if there were viruses in the pathogenesis of histiocytic necrotizing lymphadenitis (Kikuchi disease, KD). Methods Thirty cases of KD from archive of the department of pathology were selected, cut, HE and immunohistochemically stained to investigate the possibility of virus infection. Five cases of nonspeciafic lymphadenitis (NLD) were studied as control at the same time. Results In all the cases of KD and NLD no HBsAg staining in the tissues was found,but there were high expressions of HPV in KD and NLD (66 7% and 60% respectively). HSV 2 positive reaction was found in some patients of KD(40%)and NLD (20%). Furthermore, EB reaction was found in 36 6% (11/30) KD patients but not in patients with NLD. Conclusions Some viruses including HBsAg, HPV and HSV 2 may not be pathogenetic to the KD. That high EBV infection rate is found in KD but not in NLD implicated that the association between EB virus and KD deserve to be further explored.

关 键 词：组织细胞坏死性淋巴结炎 病毒学 免疫表型 病毒病因学 感染率 

分 类 号：R632.6[医药卫生—外科学]