电烧伤患者血清肌酸磷酸激酶变化与电烧伤肌肉坏死感染的关系  

Change in serum creatine phosphokinase level in patients with electric burn and its relation with the infection and necrosis of the burn muscle

作　　者：黄大伟[1] 李文慧[1] 

机构地区：[1]怀化市第一人民医院十四病室,湖南怀化418000

出　　处：《中国烧伤创疡杂志》2004年第1期20-22,共3页The Chinese Journal of Burns Wounds & Surface Ulcers

摘　　要：目的 :探讨血清肌酸磷酸激酶 (craetinephosphokinase ,CK)及其同工酶 (CK MM )的变化对电烧伤患者肌肉感染、坏死的诊断价值。方法 :高压电击伤与电弧烧伤各 4 0例 ,分为A、B两组 ,A组为手术证实有明显的肌肉坏死者 ,B组为手术证实无肌肉坏死者。分别监测患者伤后、术前及术后血清CK MM的浓度 ,同期进行血、尿常规 ,肝、肾功能检查 ,并以 30例正常人血清CK MM值作为对照。结果 :(1)A组伤后及扩创术后 1天血清CK MM的浓度显著升高 ,达正常对照组的 5倍 ;术后 3天降至正常 ,其变化与手术所见、外周血白细胞计数变化相一致 ;(2 )B组植皮术前及术后CK MM值轻度升高。结论 :CK MM可作为电击伤肌肉感染坏死的监测指标 。Objective: To evaluate the diagnostic value of the change in serum creatin phosphokinase (CK) and its isozymes (CK-MM) in muscular infection and necrosis of patients with electric burn. Method: Forty patients were divided into A and B groups according to the cause of burn. Those with electric injury were in group A and those with electric arc flame burn in group B. Serum CK-MM level was determined after injury, and before and after operations. Simultaneously, blood and urine routine, hepatic and renal function were examined and compared with those of 30 healthy persons. Result: Serum CK-MM level in group A increased significantly after injury and 1 day after wound debridement, up to 5 times of the healthy persons. Then lowered down to normal in 3 days after operation. Serum CK-MM level in group B increased slightly before and after operation. Conclusion: Serum CK-MM level can be used for monitoring muscle infection and necrosis in patients with electric burn. This method is highly specific and sensitive.

关 键 词：肌酸磷酸激酶 同工酶 电击伤 电弧烧伤 

分 类 号：R647[医药卫生—外科学]