糖尿病大鼠血液流变学的动态观察  

The Experimental Study on Hemorrheology in Diabetic Rats

作　　者：何剑峰[1] 杜娟[1] 李向荣[1] 黄艳霞[1] 

机构地区：[1]广西柳州市人民医院,柳州545001

出　　处：《中国血液流变学杂志》2004年第1期52-53,58,共3页Chinese Journal of Hemorheology

基　　金：广西自然科学基金资助 (基金号 :桂科自 0 0 0 70 3 6)

摘　　要：目的　观察糖尿病大鼠不同病程阶段血液流变学的变化。方法　将 30只Wister大鼠分为实验组与正常对照组。实验组用链脲佐菌素 (Streptozocin ,STZ)诱发糖尿病。并于糖尿病发病后 4、6和 12周对两组大鼠进行全血粘度、血浆粘度、红细胞压积、纤维蛋白原、红细胞聚集性及血液流变触性等检测及分析。结果　在各实验时点 ,糖尿病大鼠全血粘度、血浆纤维蛋白原及红细胞聚集指数明显高于正常对照组大鼠 (P <0 .0 1) ,血液流变触性则明显低于正常对照组大鼠 (P <0 .0 1) ,这些改变随糖尿病病程的延长而更趋显著 ,但血浆粘度和红细胞压积则轻微升高。结论　糖尿病大鼠血液流变异常的主要特征是红细胞聚集性增强和解聚困难 ,这可能参与糖尿病视网膜病变等糖尿病血管性并发症的发生和发展。Objective To observe the changes of hemorrheology in the rats during different stage after the occurrence of diabetes.Methods Thirty wister rats were ustd in this study for two groups,experiment and control.The rats in experiment group were induced diabetes with streptozocin.Blood viscosity,plasma viscosity,hematocrit.Fibrinogen,sympexis,and thixotropy were investigated in 4,6,and 12 weeks after the occurrence of diabetes.Results During the experimental period,the result showed that level of fibrinogen in plasma,blood viscosity,and sympexis index in diabetic rats were markedly higher than those in the control subjeects;the thixotropy index was significantly lower than that in the control group.With lengthening of the course of diabetes,those changes were more evident.But plasma viscosity and hematocrit increased slightly.Conclusion The characteristic of the changes of blood hemorrheology in the diabetic rats is the enhancement of sympexis and the difficulty of separating sympexis.In may be contributing in the occurrence and development of diaberic vascular complication,as diabetic retinopathy.

关 键 词：糖尿病 大鼠 血液流变学 动态分析 

分 类 号：R587.1[医药卫生—内分泌]