测定双嘧达莫的化学发光新方法  

Chemiluminescence Method for Determination of Dipyridamole

作　　者：饶志明[1] 张旺华[1] 李求忠[1] 谢国平[1] 杨辉琴[1] 

机构地区：[1]漳州师范学院化学系,福建漳州363000

出　　处：《光谱学与光谱分析》2004年第3期278-280,共3页Spectroscopy and Spectral Analysis

摘　　要：提出了双嘧达莫与高锰酸钾和罗丹明B的化学发光新体系 ,并发现表面活性剂吐温 80可显著增强该体系的化学发光 ,据此建立了流动注射化学发光测定双嘧达莫的新方法。该方法选择性好 ,灵敏度高 ,线性范围宽 ,双嘧达莫在 5 0× 10 -8～ 5 0× 10 -5g·mL-1范围内与发光信号呈线性关系 ,检出限 1 7× 10 -8g·mL-1,RSD为 1 1% (n =11,cs=1 0× 10 -6g·mL-1双嘧达莫浓度 )。A new system for the determination of dipyridamole with flow injection chemiluminescence was described. It is based on the chemiluminescence reaction of dipyridamole-potassium permanganate with rhodamine B. Tween-80 was found to be an enhancer of the chemiluminescence reaction. A method based on the enhanced chemiluminescence for dipyridamole determination has been developed. The method has high sensitivity, selectivity and good repeatability with a linear concentration range of 5.0 x 10(-8)-5.0 x 10(-5) g(.)mL(-1), a detection limit of 1.7 x 10(-8) g(.)mL(-1) and a RSD of 1.1% (n = 11, c(s) = 1.0 x 10(-6) g(.)mL(-1)).

关 键 词：双嘧达莫 化学发光方法 高锰酸钾 罗丹明B 流动注射 心血管系统药物 片剂 含量测定 吐温-80 

分 类 号：R972[医药卫生—药品] R927.2[医药卫生—药学]