Protopine对肠鼠心乳头肌动作电位和收缩力的影响  

Effects of protopine on Action Potential and Contractility of Isolated Papillary Muscles from the Guinea Pig

作　　者：滕初兴[1] 陈植和[1] 赵更生[2] 

机构地区：[1]昆明医学院药理教研室 [2]西安医科大学药理教研室

出　　处：《昆明医学院学报》1989年第1期44-46,共3页Journal of Kunming Medical College

摘　　要：采用常规微电极技术,用离体肠鼠心乳头肌观察了Protopine对正常心肌细胞动作电位和收缩力的影响。结果表明:Protopine产生浓度依赖性负性肌力作用。Vmax也呈现浓度依赖性降低,APD20、APD50、APD90不呈现浓度依赖性变化,但ERP随Protopine的浓度增加不断延长。提示Protopine的抗心律失常作用可能与ERP的延长有关。We observed the influence of protopine on action potential of isolated papillary muscles from the guinea pig using microelectrode technique. Protopine produced negative concentration-dependent inotropic effect.V_(max) was reduced by protopine also in a concentration-dependent manner. The changes of APD_(20), APD_(50) and APD_(90) were not concentration-dependent, but ERP was prolonged gradually following the increase of protopine concentration. These results suggest that the antiarrhythmic effect of protopine can be explained by the prolongation of ERP.

关 键 词：普罗托品 乳头肌 动作电位 收缩力 

分 类 号：R972.2[医药卫生—药品]