2-十四烷基-DTPA及其钆(Ⅲ)螯合物的合成与表征(英文)  

Synthesis and Characterization of 2-Tetradecyl-DTPA and Its Gd(Ⅲ) Chelate

作　　者：冯志明[1] 李峰[1] 朱小娟[1] 陈蓉[1] 李晓如[2] 

机构地区：[1]湖南师范大学化学化工学院,长沙410081 [2]中南大学化学化工学院,长沙410083

出　　处：《无机化学学报》2004年第5期547-550,共4页Chinese Journal of Inorganic Chemistry

基　　金：湖南省科技厅资助项目(No.OOSSY1013鄄51)。

摘　　要：Synthesis and characterization of the ligand, [2-tetradecyl-3,6,9-tris(carboxymethyl)-3,6,9-triazaundecan-1,11-dioic acid, H5L] and its Gd(Ⅲ) chelate are described. Protonation constants for H5L (lgKiH = 10.80, 8.40, 4.30, 2.80, 2.15) and the stability constant for GdL2- (lgK■ = 22.75) were determined by potentiometric titration and are similar with the related values of DTPA and Gd-DTPA respectively. The results obtained show that the basicity of the ligand and the stability constant of its Gd(Ⅲ) chelate are not obviously altered after introduction of a linear chain tetradecyl group at the terminal acetic acid residue of DTPA.Synthesis and characterization of the ligand, [2-tetradecyl-3,6,9-tris(carboxymethyl)-3,6,9-triazaundecan-1,11-dioic acid, H5L] and its Gd(Ⅲ) chelate are described. Protonation constants for H5L (lgKiH = 10.80, 8.40, 4.30, 2.80, 2.15) and the stability constant for GdL2- (lgK■ = 22.75) were determined by potentiometric titration and are similar with the related values of DTPA and Gd-DTPA respectively. The results obtained show that the basicity of the ligand and the stability constant of its Gd(Ⅲ) chelate are not obviously altered after introduction of a linear chain tetradecyl group at the terminal acetic acid residue of DTPA.

关 键 词：2-十四烷基-DTPA 钆配合物 合成 表征 稳定性 

分 类 号：O614.339[理学—无机化学] O641.4[理学—化学]