男性Graves病患者唾液睾酮及血睾酮对hCG刺激试验的反应  

THE RESPONSES OF SALIVARY AND SERDM TESTOSTERONE TO hCG PROVOCATION IN ADULT MALES WITH GRAVES' DISEASE

作　　者：彭小丁[1] 潘长玉[1] 李江源[1] 罗国春[1] 郭爱岩[1] 

机构地区：[1]中国人民解放军总医院内分泌科

出　　处：《中华内分泌代谢杂志》1992年第2期88-90,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：作者探讨了8例成年男性Graves病患者唾液睾酮(ST)和血睾酮(TT)对hCG刺激的反应及基础ST/LH和TT/LH比值的变化。用硫脲类药物治疗的患者,治疗前其ST在hCG刺激反应中各时相水平、曲线下面积和ST均低于正常组,治疗后上升恢复正常;治疗前各时相TT水平及曲线下面积增高,TT增加倍数减低,治疗后以相反方向变化恢复正常,TT治疗前后均接近正常组;治疗前ST/Lh比值减低,治疗后显著上升接近正常组;TT/LH比值治疗前后差异无显著性。结果提示,Graves病患者ST及TT“分离”可能系甲亢时高SHBG血症所致,不能仅观察血TT指标,Leydig细胞功能是否受损尚不能凭hCG刺激试验及睾酮/LH比值变化确定。The responses of salivary testosterone (ST) and serum total testosterone (TT) to hCG provocation and the ratio of basal ST/LH as well as TT/LH in 8 adult males with Graves' disease were investigated. During hGG test before treatment with thioureas the ST level at each phase, the area under ST response curve, and AST value in the patients were lower than those in normal controls, and resumed to normal after treated for 12 months. The TT level at each phase and the area under TT response curve during hCG test in untreated patients were higher when compared with those in the controls. After the treatment, the above parameters of TT response in the patients were changed reversely and became comparable to the controls. The results suggested that the 'dissociation' between the parameters of ST and TT in men with Graves' disease might be ascribed to hyper-sex hormone-binding-globulinemia, and it would be misleading if only to measure the blood total testosterone level.

关 键 词：HCG 睾酮 唾液 LH 甲状腺肿 

分 类 号：R581.104[医药卫生—内分泌]