生物工程合成生长激素对生长激素缺乏性侏儒血浆氨基酸谱的影响  

ACUTE AND CHRONIC EFFECT OF R-hGH ON PLASM AFREE AMINO ACIDS IN DWARFS WITH GROWTH HORMONE DEFICIENCY

作　　者：王传丰[1] 周建德[1] 钱大龙[1] 郭华[1] 陈瑞冠[1] 

机构地区：[1]上海市儿科研究所

出　　处：《中华内分泌代谢杂志》1992年第4期208-210,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：本文对10例生长激素缺乏性侏儒症(GHD)患儿在应用生物工程合成生长激素(R-hGH)治疗初始及治疗3个月时的血浆游离氨基酸(FAA)谱进行了配对分析。治疗初始及治疗3个月时,注射R-hGH后4小时的血浆FAA中,半数以上的必需氨基酸(EAA)和大部分(8/12)非必需氨基酸(NEAA)显著减少,提示氨基酸参与了蛋白质合成及生糖生酮。治疗3个月时血浆大部分氨基酸于注射后4小时显著减少的程度不及治疗初始,可能为机体对较长时间hGH治疗的代谢适应。与治疗初始比较,R-hGH治疗3个月时间的空腹血浆FAA总值和尿素显著低下,提示机体氮排出减少和保留增加,多用于合成NEAA。甘氨酸、脯氨酸、谷氨酸等明显低下,说明骨组织在较高时间R-hGH作用下对氨基酸需求增加及组织之生长旺盛,亦提出应加强蛋白营养以满足生长需要。The plasma free amino acids (FAA) of 10 dwarfs with growth hormone deficiency (GHD) were analysed at the beginning of and 3 months after R-hGH treatment in order to observe the acute and chronic effect of R-hGH on plasma FAA. At the beginning of and after 3-month treatment, the levels of more than half of the essential amino acids(EAA) and most of the non-essential amino acids (NEAA) decreased dramatically 4 hours after R-hGH injection, denoting that the amino acids were consumed in protein synthesis, gluconeogenesis, and ketogenesis. The magnitudes of relevant results after 3-month treatment were not as much as those at the beginning (although still statistically significant), suggesting a mild metabolic adaptation of body to long-term R-hGH treament. The significant low value of FAA and urea in fasting blood after 3-month treatment bespeaks a nitrogen retention. The striking decrease in glycine, proline, glutamic acid etc., proposes an increased need of amino acids for bone growth after long-term R-hGH treatment. To meet the demand of body development, an increase in protein nutrition during GH therapy is recommended.

关 键 词：生长激素 氨基酸 侏儒症 儿童 

分 类 号：R584.210.5[医药卫生—内分泌]