内皮素与糖尿病大鼠早期肾损害的相关性研究  

Relationship between endothelin and early kidney injury in diabetic rats

作　　者：孟德欣[1] 付纯芳[1] 关政[1] 贾秀月[1] 李晶[1] 于翔辉[1] 

机构地区：[1]佳木斯大学基础医学院生理教研室,黑龙江佳木斯154007

出　　处：《黑龙江医药科学》2004年第2期14-15,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的 :观察糖尿病大鼠血浆和肾组织中 ET的含量变化与 2 4 h尿微量白蛋白的关系 ,为早期诊治 DN提供理论依据。方法 :Wistar大鼠 ,体重 16 0～ 2 0 0 g,于造模后第 6、8、10、12、14周测定血浆和肾组织中的 ET和 2 4 h尿微量白蛋白。结果 :血浆和肾组织中的 ET在造模后第 6周无明显改变 ,从第 8周开始呈进行性增高 ,并与 2 4 h尿微量白蛋白呈正相关。结论 :动态观察血浆和肾组织中 ET的变化对于早期发现Objective: To provide theoretic basis for preventing early kidney injury , we observed the relationship between serum endothelin or kidney tissue endothelin in diabetic rats and the quantity of uric micro-albumin in 24h. Methods:In Wistar rats ,weight 160～200g ,we measured the serum endothelin or kidney tissue endothelin in diabetic rats and the quantity of uric micro-albumin in 24h at weeks 6,8,10,12 and 14 after their diabetic models were made. Results:Serum endothelin and kidney tissue endothelin in the rat models did not obviously alter at week 6, but they much increased at week 8 and were related to the quantity of uric micro-albumin in 24h. Conclusions: The alteration of serum endothelin and kidney tissue endothelin in diabetic rats are important on early discovering and analyzing DN diabetic nephropathy.

关 键 词：内皮素 糖尿病 糖尿病肾病 

分 类 号：R587.1[医药卫生—内分泌]