+Gz致脑缺血恢复期大鼠学习能力变化的探讨  

Changing of learning ability in rats during ischemic convalescence induced by sustained +Gz exposure

作　　者：曹新生[1] 吴兴裕 孙喜庆[1] 刘挺松[1] 

机构地区：[1]第四军医大学航空航天医学系航空航天生物动力学教研室,陕西西安710033

出　　处：《第四军医大学学报》2004年第1期79-81,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金 (3980 0 1 58) ;军队留学回国人员科研启动基金 (0 1H0 2 8)

摘　　要：目的 :探讨持续性正加速度 (+Gz)暴露后 ,缺血恢复期大鼠学习训练能力的改变 .方法 :雄性SD大鼠 2 4只随机等分为对照组、+6Gz组和 +1 0Gz组 ,观察不同G值 +Gz作用后 ,0 (即刻 ) ,2 ,4和 6d大鼠学习能力的变化 .结果 :辨别性学习能力 +6Gz和 +1 0Gz组大鼠的正确反应次数较对照组均显著降低 (P <0 .0 1 ) ,反应时均显著延长 (P <0 .0 1 ) ,+6Gz组正确次数较 +1 0Gz组显著增加 (P <0 .0 5 ) ;被动回避反应观察发现 +6Gz组和 +1 0Gz组大鼠的 6d潜伏期较对照组显著缩短 (P <0 .0 1 ) .结论 :+Gz暴露恢复期可致大鼠学习能力的持续降低 。AIM: To investigate the changes of learning ability in rats during ischemic convalescence induced by sustained positive acceleration (+Gz) exposures. METHODS: Twenty four male SD rats were randomly divided into 3 groups: control group (C), +6 Gz/3 min group (+6 Gz), and +10 Gz/3 min group (+10 Gz). The changes of learning in rats were measured at 0 d(after +Gz exposure immediately), 2 d, 4 d and 6 d after different +Gz exposure. RESULTS: In Y maze test,the right number decreased significantly ( P <0.01),and time of reaction increased significantly ( P <0.01) in +6 Gz and +10 Gz group compared to that in control group; the right number increased significantly in +6 Gz group compared to +10 Gz group ( P <0.05). In step through test, latent time at 6 d in experimental groups shortened significantly compared to control group ( P <0.01). CONCLUSION: It is suggested that +Gz exposure could impair learning ability of rats extendedly, and increased G level could deteriorate this effect.

关 键 词：加速度 学习 大鼠 

分 类 号：R852.21[医药卫生—航空、航天与航海医学]