中枢性尿崩症50例病因及治疗分析  

Etiology and therapy of central diabetes insipidus in 50 cases

作　　者：洪茜萍[1] 

机构地区：[1]天津医科大学总医院儿科,天津300052

出　　处：《实用儿科临床杂志》2004年第4期257-258,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的　探讨小儿中枢性尿崩症的病因及治疗措施。方法　对中枢性尿崩症 5 0例患儿临床资料、实验室检查结果、病因及治疗方法进行总结。结果　 1.病因 :以特发性居多 ,继发性中以肿瘤为最多见 ,遗传性仅 1例。 2 .治疗 :肿瘤以手术及放疗为主 ,其他以补充激素为主。结论　对中枢性特发性尿崩症患儿应询问家族史 ,其中有些病例可能属遗传性中枢性尿崩症 ,因抗利尿激素基因突变所致。MRI对早期诊断及追踪治疗有重要意义。Objective To explore the etiology and therapy of central diabetes insipidus (CDI) in children.Methods To analyze 50 cases of CDI including clinical manifestation, laboratory data, etiology and therapy.Results 1.Etiology:idiopathic CDI occupied the most cause, the next was the secondary CDI including tumors, and there was only one case of hereditary CDI. 2.Therapy: tumors were treated by surgery and radiotherapy, the rest were mainly treated with hormone substitution.Conclusions Family history is helpful in diagnosing hereditary CDI caused by gene mutations ,otherwise it may be misdiagnosed as idiopathic CDI. MRI is significant in early diagnosis and helpful during follow-up. Minirin is more effective and safer in the therapy of CDI.

关 键 词：尿崩症 中枢性 弥凝替代治疗 神经垂体 

分 类 号：R725.8[医药卫生—儿科]