益肾活血胶囊对肾性贫血大鼠血浆红细胞生成素的影响  

Effects of YiShenHuoXue Capsule on erythropoietin in rats with chronic renal anemia

作　　者：孙万森[1] 吴喜利[1] 乔成林[1] 崔大江[1] 

机构地区：[1]西安交通大学第二医院中西医结合科,陕西西安710004

出　　处：《第四军医大学学报》2004年第5期410-411,共2页Journal of the Fourth Military Medical University

基　　金：陕西省自然科学基金 (97SM38)

摘　　要：目的 :研究益肾活血胶囊 (YSWX)对慢性肾功能不全性贫血大鼠血浆红细胞生成素含量及肾功能的影响 .方法 :用腺嘌呤建立大鼠肾性贫血模型 (n =30 ) ,用YSWX进行防治 .结果 :经过益肾活血胶囊治疗 ,大鼠肾功能明显改善(BUNmmol/L :1 7.5± 3.6vs 2 8.5± 1 0 .6 ,P <0 .0 1 ;1 2 .2±3.2vs 2 8.5± 1 0 .6 ,P <0 .0 1 ;SCrμmol/L :1 0 9.1± 1 0 .2vs72 .1± 7.6 ,P <0 .0 1 ;93.9± 1 1 .7vs 72 .1± 7.6 ,P <0 .0 1 ) ,EPO含量 (CFU E)明显升高 ,和病理组比较差异显著(CFU E :1 1 .5± 3.4vs 6 .5 8± 2 .1 ,P <0 .0 1 ;1 3.2± 3.6vs6 .5 8± 2 .1 ,P <0 .0 1 ) .结论 :益肾活血胶囊具有改善肾功能 。AIM: To investigate the effects of YiShenHuoXue Capsule (YSWX) on erythropoietin and renal function in rats with chronic renal anemia. METHODS: The rat models of chronic renal anemia were established with adenine ( n =30) and then were treated with YSWX. RESULTS: YSWX significantly improved the rats' renal function (BUN mmol/L: 17.5±3.6 vs 28.5±10.6, P <0.01; 12.2±3.2 vs 28.5± 10.6, P <0.01; SCr μmol/L:109.1±10.2 vs 72.1±7.6, P <0.01; 93.9±11.7 vs 72.1±7.6, P <0.01) and increased the erythropoietin level in plasma (CFU E;11.5±3.4 vs 6.58±2.1, P <0.01; 13.2±3.6 vs 6.58±2.1, P <0.01). CONCLUSION: YSWX can improve rat renal function and increase erythropoietin level in plasma.

关 键 词：益肾活血胶囊 慢性肾性贫血 肾功能 促红细胞生成素 

分 类 号：R255[医药卫生—中医内科学] R749[医药卫生—中医学]