妊娠期瘦素水平与新生儿生长发育的关系  

Relationship Between Serum Leptin Level and Growth of Neonates During Pregnancy

作　　者：朱鋐达[1] 王敏敏[2] 唐金凤[1] 金燕[1] 侍庆[2] 陈名道[1] 

机构地区：[1]上海第二医科大学瑞金医院内分泌代谢科,上海市内分泌研究所上海200025 [2]上海第二医科大学瑞金医院妇产科,上海市内分泌研究所上海200025

出　　处：《上海第二医科大学学报》2003年第3期237-239,242,共4页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的 观察妊娠期孕妇瘦素水平与新生儿性别、身长、体重的关系,比较母血、脐血、羊水中瘦素浓度。方法 对224名孕妇测定妊娠过程中的血清瘦素水平。其中32名孕妇,在分娩时检测母体血清、脐血和羊水中的瘦素浓度,并分析三者之间的关系。 结果 妊娠期血清瘦素水平与孕妇的体重指数、体重、腹围及舒张压均呈正相关(P<O.05或P<0.01)。按新生儿性别分组后,二组的母体血清瘦素水平无显著性差异。分组后母体的血清瘦素水平仍与孕妇的体重、体重指数、腹围及舒张压呈显著正相关(P<0.05或P<0.01)。在分娩时,母血的瘦素浓度高于脐血,羊水瘦素浓度最低,三者相比差异均有显著性(P<0.01),且母血的瘦素浓度与羊水瘦素浓度呈正相关(P<0.05)。结论 妊娠期女性的血清瘦素水平与孕妇的体重、腹围和舒张压相关。分娩时母血、脐血和羊水的瘦素水平差异明显,母血瘦素浓度与羊水瘦素浓度相关。新生儿的性别对母体妊娠期瘦素水平没有明显的影响。Objective To investigate the effect of maternal serum leptin level during pregnancy on the neonates' growth and the relationship between the leptin levels in maternal blood, umbilical cord blood and amniotic fluid. Methods Two hundred and twenty -four pregnant women were included in the study, and serum leptin concentrations were measured with the RIA method. After delivery, these subjects were divided into two groups according to the neonates' gender, and relationships between maternal serum leptin and neonates' gender and growth were analyzed. In 32 subjects, the leptin concentrations in maternal blood, umbilical cord blood and amniotic fluid were measured and compared. Results In the subjects studied, the serum leptin level correlated significantly to the body mass index, body weight, abdomen circumference and diastolic blood pressure(P <0.05 or P <0.01). The maternal serum leptin level also correlated significantly to their body weight, body mass index, abdomen circumference and diastolic blood pressure (P <0.01 or P < 0. 05). No difference of serum leptin level was found between the two groups. At delivery, the leptin concentration in maternal blood was higher than that in umbilical cord, and the latter was higher than that in amniotic fluid (P <0. 01). Positive correlation was found between the leptin levels in maternal blood and amniotic fluid (P<0. 05). Conclusion It is similar to the non -pregnant persons; serum leptin levels of pregnant women correlate to their body weight and the body mass index during pregnancy, and they also correlate to the abdomen circumference and diastolic blood pressure. The leptin concentrations are significantly different among maternal blood, umbilical cord and amniotic fluid, and the leptin level in maternal blood correlates to that in amniotic fluid. The neonates' gender may not affect the maternal blood leptin level during pregnancy.

关 键 词：妊娠期 瘦素 新生儿 血清学检查 脐血 母血 放射免疫法 

分 类 号：R714.147[医药卫生—妇产科学]