356株淋病奈瑟菌对抗菌药物敏感性的分析  

Analysis of the Antibiotic Susceptibility in 356 Epidemic Strains of Neisserria Gonorrhoeae

作　　者：韩榜成 易顺强 颜秉兴 高胜旗 董玲 傅世珍[2] 毛虎[3] 

机构地区：[1]中原油田总医院,河南濮阳457001 [2]郑州大学第一附属医院,河南郑州450052 [3]洛阳市中心医院,河南洛阳471009

出　　处：《中国皮肤性病学杂志》2003年第6期388-389,392,共3页The Chinese Journal of Dermatovenereology

基　　金：河南省科学攻关项目 ( 0 1 2 4 1 70 74 9)

摘　　要：目的　了解淋病奈瑟菌对青霉素、四环素、环丙沙星、头孢曲松、红霉素、卡那霉素、庆大霉素、壮观霉素、诺氟沙星、氧氟沙星和头孢噻肟的敏感性。方法　用纸片和琼脂稀释法测定药物敏感性 ,测定β 内酰胺酶。结果　 3 56株淋病奈瑟菌对头孢曲松、头孢噻肟和壮观霉素的耐药性分别增至 7.6% ,9.4%和 2 4.5% ,其余药物的耐药性均显著增加 ;检出 β 内酰胺酶阳性菌 81株。结论　河南地区淋病奈瑟菌对青霉素、四环素、红霉素、诺氟沙星、氧氟沙星的耐药性相当高 ,对头孢曲松、头孢噻肟和壮观霉素的耐药性有增加趋势 。Objective To determine antibiotic susceptibili ties of penicillin,tetracycline,ciprofloxacin,ceftriaxone,erythromycin,kanamyci n,gentamicin,spectinomycin,norfloxacin,ofloxacin,cefotaxime for epidemic neisser ia gonrrhoeae.Methods Antimicrobial susceptibility testing was performe d using slip and lavor carang diffusion,and Beta-lactamase was tested.Results 356 strains gonococcus to ceftriaxone,cefotaxime, spectinomycin rose to 7.6%,9.4%,24.5% respectively.The gonococcus tolerance to t he other antibacterials rose significantly.There were 81 strains of beta-lactam ase-positive among epidemic neisseria gonrrhoeae.Conclusion The study suggested that penicillin,tetracycli ne erthromycin and some of quinolones resistant strains of gonococci in Henan pr ovince were severe rose.Three antibiotics,including ceftriaxone,cefotaxime,spect inomycin,can be used as head drug in treatment gonorrhoeae though there were the increasing tendency of the gonococcus tolerance to them.

关 键 词：淋病奈瑟菌 抗菌药物 药物敏感性 测定 Β-内酰胺酶 最小抑菌浓度 

分 类 号：R378.16[医药卫生—病原生物学] R978.1[医药卫生—基础医学]