奥美拉唑与法莫替丁预防呼吸衰竭并发应激性溃疡的对比研究  

Compare Study of Omeprazole vs Famotidin Treating Stress Ulcer Complicatory with Respiratory Failure

作　　者：林学壬[1] 肖伟民[1] 李伟明[1] 刘林[1] 胡杨真[1] 

机构地区：[1]暨南大学医学院第五附属医院[广东省清远市人民医院],清远511500

出　　处：《中国临床医学》2004年第1期34-35,共2页Chinese Journal of Clinical Medicine

摘　　要：目的 :了解奥美拉唑与法莫替丁对预防呼吸衰竭并发应激性溃疡的疗效。方法 :将慢性阻塞性肺病 (慢阻肺 )、肺源性心脏病 (肺心病 )并发呼吸衰竭患者 77例 ,随机分为奥美拉唑治疗组 39例及法莫替丁对照组 38例 ,对照两组上腹痛、反酸、上消化道出血发生率及上消化道出血所致的病死率。结果 :治疗组上腹痛、反酸、上消化道出血发生率及上消化道出血所致的病死率分别为 5 .13%、7.6 9%、2 .5 6 %、0 % ,对照组分别为 2 3.6 8%、34.2 1%、2 1.0 5 %、13.16 % ,差异均显著 (P <0 .0 5 )。结论 :奥美拉唑更能减少慢阻肺、肺心病并呼吸衰竭时应激性溃疡的发生 。Objective: To study the effects of omeprazole vs famotidin treating stress ulcer complicatory with respiratory failure. Methods:77 patients of chronic obstructive pulmanary emphysema and chronic cor pulmonale complicating with stress ulcer were randomly divided into two groups , omeprazole group (n =39) and famotidin group( n =38), to analyse the incidence of epigastric pain, sour regurgitation, upper digestive tract hemorrhage and mortality caused by upper digestive tract hemorrhage. Results:The incidence of epigastric pain, sour regurgitation, upper digestive tract hemorrhage and mortality was 5.13% 7.69%, 2.56%, 0% in omeprazole group, and 23.68%,34.21%, 21.05%, 13.16% in famotidin group, respectively. The statistical differences were significant between two group( P <0.05). Conclusion:Omeprazole can decrease the incidence of stress ulcer complicated with chronic obstructive pulmanary emphysema and chronic cor pulmonale to lower the mortality caused by upper digestive tract hemorrhage.

关 键 词：奥美拉唑 法莫替丁 预防 呼吸衰竭 并发症 应激性溃疡 

分 类 号：R563.8[医药卫生—呼吸系统] R573.1[医药卫生—内科学]