黄连花中两个新的三萜皂苷  

Two new triterpenoid saponins from Lysimachia davurica

作　　者：田景奎[1] 邹忠梅[1] 徐丽珍[1] 张宏武[1] 穆红梅[1] 杨世林[1] 

机构地区：[1]中国医学科学院,中国协和医科大学药用植物研究所,北京100094

出　　处：《药学学报》2004年第3期194-197,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 (3 9870 0 85 );国家"九五"攻关课题 (96-90 1-0 6-3 7)

摘　　要：目的　对黄连花 (LysimachiadavuricaLedeb .)全草的三萜皂苷成分进行分离和结构鉴定。方法　通过大孔树脂纯化 ,硅胶和反相硅胶色谱分离正丁醇萃取物物中的三萜皂苷 ;利用多种波谱技术并结合酸水解方法鉴定其化学结构。结果　分离鉴定了 2个三萜皂苷 ,其结构分别为 3β ,16α ,2 9 三羟基 13,2 8 环氧 齐墩果烷 3 O β D 吡喃葡糖基 (1→ 2 ) β D 吡喃葡糖酸甲酯苷 (I) ,3β,16α ,2 8 三羟基 齐墩果 12 烯 3 O { β D 吡喃葡糖基 (1→ 2 ) β D 吡喃葡糖醛酸 } 2 8 O β D 吡喃葡糖苷 (II)。结论　化合物I和II为新的三萜皂苷 ,分别命名为黄连花皂苷D和J。Aim To study the triterpenoid saponins in the whole plant of Lysimachia davurica Ledeb. Methods Column chromatography (including AB-8 macroporous resin, silica gel and ODS) was used to separate triterpenoid saponins whose structures were elucidated by ESI-MS, NMR (1D and 2D) and hydrolysis methods. Results Two new triterpenoid saponins were isolated and established as 3β,16α,28-trihydroxy-olean-12-en-3- O -｛β- D -glucopyranosyl-(1→2)-β- D -glucuronopyranosyl｝-28- O -β- D -glucopyranoside｝ (I), 3β,16α,28-trihydroxy-olean-12-en-3- O -｛β- D -glucopyranosyl-(1→2)-β- D -glucuronopyranosyl｝-28- O -β- D -glucopyranoside｝ (II). Conclusion Compounds I and II are new compounds and named as davuricosides D and J.

关 键 词：黄连花 三萜皂苷 成份分离 结构鉴定 

分 类 号：R282.71[医药卫生—中药学]