维持性血液透析尿毒症患者sICAM-1和E-选择素水平的变化  

Changes of intercellular adhesion molecule-1 and E-selectin levels in plasma of uremic patients treated with maintaining hemodialysis

作　　者：李振江[1] 徐月清[1] 陈威[1] 谭华[1] 

机构地区：[1]第四军医大学西京医院肾内科,陕西西安710032

出　　处：《细胞与分子免疫学杂志》2004年第2期219-221,共3页Chinese Journal of Cellular and Molecular Immunology

摘　　要：目的 :测定维持性血液透析 (MHD)的尿毒症患者血浆中细胞间黏附分子 1(ICAM 1)和E 选择素的水平 ,探讨MHD患者动脉粥样硬化的病理机制。方法 :应用双抗夹心ELISA法 ,测定 10 5例MHD患者和 2 5例健康人 (对照组 )血浆中ICAM 1和E 选择素的水平 ,同时用B超测定患者颈动脉粥样硬化的情况 ,记录两组的血压并测定其血脂、血糖、血尿素和肌酐的水平。结果 :①MHD组血浆ICAM 1和E 选择素的水平均明显高于对照组 (P <0 .0 1)。MHD组中 ,有颈动脉硬化者血浆I CAM 1和E 选择素的水平明显高于无颈动脉硬化组 (分别为P <0 .0 1和P <0 .0 5)。②MHD组血浆ICAM 1与E 选择素以及与甘油三酯 (TG )均呈显著的正相关 (r值分别为0 .62及 0 .60 )。血浆ICAM 1的水平与舒张压也呈正相关(r=0 .41)。结论 :MHD患者存在明显的血管内皮功能损伤。血浆ICAM 1和E 选择素可作为MHD患者血管内皮损伤的标志物 。AIM: To detect the levels of ICAM-1 and E-selectin in plas mas from uremic patients treated by means of maintaining hemodialysis (MHD) and explore the pathological mechanism of atherosclerosis in MHD patients. METHODS: The levels of ICAM-1 and E-selectin in plasmas from the 105 MHD patients and 25 healthy persons (control group) were detected by dual antibo dy sandwich ELISA. The cervical atherosclerosis of the patients was examined by type B ultrasonography. Simultaneously, the blood pressures of the patients and control group were taken and recorded, as well as the biochemical criterions in their blood were detected. RESULTS: ① The plasma levels of ICA M-1 and E-selectin in MHD patients were significantly higher than those in the control group, respectively (P<0.01), and in MHD group the above indexes in patients with cervical atherosclerosis were significantly higher than those wi thout cervical atherosclerosis (P<0.01, P<0.05). ② In MHD group, the pl asma ICAM-1 level was positively correlated with E-selectin and triglycerides (TG) levels (r=0.62 and 0.60, respectively), and with the diastolic pressure (r=0.41, P<0.05). CONCLUSION: The impai rment of vascular endothelial function was obvious in uremic patients with MHD. The changes of ICAM-1 and E-selectin could be accepted as biochemical criterio ns of vascular endothelial injury. The two adhesion molecules have close relatio nship with atherosclerosis in MHD patients.

关 键 词：细胞间黏附分子-1 E-选择素 动脉粥样硬化 尿毒症 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]