胎儿脐血清β_(2-)微球蛋白在产前评估胎儿肾功能的探讨  

Investigation of fetal renal function with umbilical serum β_2-microglobulin

作　　者：冯穗华[1] 方群[1] 王昌云[1] 陈健生[1] 董秀清[2] 何惠娟[2] 陈筠红[1] 王彩玲[1] 

机构地区：[1]中山大学附属第一医院胎儿医学中心,广州510080 [2]中山大学附属第一医院肾内科,广州510080

出　　处：《中华肾脏病杂志》2003年第3期164-167,共4页Chinese Journal of Nephrology

摘　　要：目的 探讨胎儿脐血清β_2-微球蛋白(β_2-m)对胎儿肾功能的评估价值。方法 用放射免疫法分别检测13例产前B超诊断为泌尿系畸形胎儿及34例经产前诊断正常胎儿的脐血清中β_2-m含量。结果 正常对照组胎儿血清β_2-m为(4.21±0.61)mg/L,泌尿系畸形胎儿血清β_2-m为(6.27±3.26)mg/L,两组β_2-m水平差异有显著性意义(P<0.05)。结论 妊娠18～40周正常胎儿血清β_2-m水平不随孕周变化;泌尿系畸形胎儿血清β_2-m升高预示肾小球滤过率降低,有望成为评估胎儿肾功能的一项指标。Objective To investigate the value of umbilical serum β2-microglobulin(β2-m) in evaluation of fetal renal function. Methods Cordocentesis was performed on 13 fetuses with congenital urological deformities and 34 normal fetuses without evidences of urological deformities. Umbidical serum β2-m was measured by radioimmunoassay. Results The value of umbilical serum β2-m was(6. 27±3. 26) mg/L in congenital urological deformities, which was significantly higher than that in normal control group [ (4. 21 ±0.61) mg/L, P < 0. 05 ] . Conclusions The value of fetal umbilical serum β2-m does not change significantly during 18-40 gestation age. Increased value of serum β2-m in the fetuses with urological deformities indicates a reducing glomerular filtration rate, and may be used as an index of renal function.

关 键 词：胎儿 脐血清 Β2-微球蛋白 产前诊断 肾功能 放射免疫法 肾小球滤过率 先天性泌尿系畸形 

分 类 号：R714.5[医药卫生—妇产科学]