相对静息期的增生性瘢痕和瘢痕疙瘩中Ⅳ型胶原的分布及表达  

Expression and histological distributive characteristic of IV Collagen in relative resting hypertrophic scar and keloid

作　　者：周智[1] 李荟元[1] 马福臣[2] 鲁开化[1] 张传山[2] 胡佩珍[2] 

机构地区：[1]第四军医大学西京医院整形外科中心,陕西省西安市710032 [2]第四军医大学西京医院病理科

出　　处：《中国美容医学》2003年第3期249-250,共2页Chinese Journal of Aesthetic Medicine

摘　　要：目的:了解Ⅳ型胶原在相对静息期增生性瘢痕、瘢痕疙瘩中的表达与作用。方法:利用免疫组化的方法检测Ⅳ型胶原在瘢痕中的分布及表达。结果:在所有的病理性瘢痕标本中均有Ⅳ型胶原的表达,在增生性瘢痕中的表达强于而且多于瘢痕疙瘩中的表达。表达区域在瘢痕表皮的基底膜层、血管和皮肤附件的周围。与凋亡相关基因的表达几乎一致。结论:提示我们Ⅳ型胶原与相对静息期增生性瘢痕和瘢痕疙瘩的转归有着重要的关系。Objective : To study the expression and histological distributive characteristic and effect in relative resting hypertrophic scar and keloid. Methods : Utilize Immunohistochemistry to detect the expression and distributing of IV Collagen in relative resting hypertrophic scar and keloid. Results: The expression of IV collagen was detected in all of the sample of relative resting hypertrophic scar and keloid. The area of expression was in basal layer of scar epidermis, perivascular and skin appendages, and the intensity of expression in hypertrophic scar was higher than in keloid. Conclusion: It indicates that IV collagen may paly an important role in the change of relative resting hypertrophic scar and keloid.

关 键 词：分布 表达 增生性瘢痕 瘢痕疙瘩 Ⅳ胶原 免疫组化 

分 类 号：R619.6[医药卫生—外科学]