^(131)I治疗Graves’病后发生甲低与TGA,TMA及TRAb的关系  

Serum Thyroid Auto-antibody Contents in GD Patients Developing Hypothyroidism After ^(131)I Treatment

作　　者：曹慧玲[1] 孙丽娟[1] 季晓鹏[1] 赵明[1] 

机构地区：[1]大连医科大学附属第二医院核医学科,116027

出　　处：《放射免疫学杂志》2004年第2期93-95,共3页Journal of Radioimmanology

摘　　要：目的 :从甲状腺自身免疫方面探讨1 3 1 I治疗甲亢的效果及甲低发生的因素。方法 :选择1 3 1 I治疗的88例Graves’病甲亢患者随访 3年 ,分为第 1组 (TGA、TMA、TRAb均阳性 )和第二组 (TGA、TMA阴性 ,TRAb阳性 )。采用x2 分析自身抗体水平与甲低发生的关系。结果 :1组甲低发生率为 31 4 % ,2组为 3 8% ,1组明显高于 2组 ,差异有显著性。结论 :TGA、TMA和TRAb水平与确定1 3 1 I剂量及甲低的发生关系密切。认为TGA、TMA水平高的患者应酌情减少1 3 1Objective To explore the auto-immune factors predisposing to developing, hypothyroidism after 131 I treatment in patients with Graves' disease (GD). Methods Eighty-eight GD patients treated with 131 I were followed for three years. These patients were of two groups: Group A (n=35), serum TGA,TMA,TRAb all positive before treatmnet; Group B (n=53) serum TGA, TMA negative but TRAb positive. Results In Group A, 31.40% (n=11) of all the patients were hypothyroid three years after treatment. The result was much better in Group B, with only 3.8% (n=2) being hypothyroid. The difference was significant. Conclusion GD patients with positive TGA, TMA were liable to develop hypothyroidism after 131 I treatment. Those patients should be treated with lesser amount of the drug accordinly.

关 键 词：Graves’病 TMA TRAB TGA 甲状腺功能减退症 碘放射性同位素 促甲状腺激素受体抗体 

分 类 号：R581[医药卫生—内分泌]