血管紧张素Ⅱ-1型受体拮抗剂对阿霉素肾病大鼠干预效果的实验研究  

Intervention of Angiotensin Ⅱ receptor antagonist valsartan on rat of adrimycin nephrosis

作　　者：尹忠诚[1] 刘娅[2] 李胜开[1] 陆明雪[1] 

机构地区：[1]徐州医学院附属医院肾内科,221002 [2]徐州市中心医院儿科

出　　处：《江苏医药》2004年第4期284-286,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅课题 (Z990 5 )

摘　　要：目的　探讨血管紧张素Ⅱ 1受体拮抗剂 (AT1RA)缬沙坦对大鼠肾病综合征病理及相关临床指标的干预作用及可能机制。方法　采用阿霉素肾病 (AN)模型 ,将大鼠分为阿霉素肾病组和缬沙坦及苯拉普利治疗组 ,检测大鼠 2 4h尿蛋白排泄量、血肌酐、尿素氮及其他生化指标 ,并取肾脏进行光镜及电镜检查 ,放射免疫分析法测定血浆及肾组织血管紧张素Ⅱ含量 ,并设正常对照组。结果　缬沙坦及苯拉普利可降低阿霉素肾病大鼠的蛋白尿排泄 ,改善生化指标。结论　缬沙坦对阿霉素肾病大鼠的肾脏具有保护效应 ,减轻肾损伤 。Objective To evaluate the effects of valsartan,specific antagonist of angiotensin Ⅱ receptors on kidney of rat with adrimycin nephrosis(AN).Methods The adrimycin nephrosis rats were treated with valsartan and benazepril.24 hour urine protein excretion,serum creatinine and blood urea nitrogen as well as renal morphological lesions were observed;angiotensin Ⅱ concentration serum and renal tissue was detected by RIA.Results In valsartan and benazepril treated rats,the proteinuria decreased compared with the untreated rats.Conclusion Valsartan partly reduces the urine protein excretion and significantly prevents renal injury in AN rats.

关 键 词：血管紧张素Ⅱ 阿霉素肾病 大鼠 缬沙坦 肾病综合征 病理特点 

分 类 号：R692[医药卫生—泌尿科学] R972[医药卫生—外科学]