神经生长因子在大鼠心内神经节的表达  

THE EXPRESSION OF NERVE GROWTH FACTOR IN THE INTRINSIC CARDIAC GANGLIA OF RAT

作　　者：刘晓柳[1] 李光千[2] 赵小明[2] 

机构地区：[1]武汉科技大学医学院解剖学教研室,武汉430080 [2]华中科技大学同济医学院解剖学系,武汉430030

出　　处：《解剖学报》2004年第1期100-102,共3页Acta Anatomica Sinica

摘　　要：目的　观察成年和中老年大鼠心内神经节神经生长因子 (NGF)阳性神经元的存在及其变化。　方法免疫组织化学法。　结果　成年及中老年大鼠心内神经节均存在NGF阳性神经元 ,但中老年大鼠心内神经节NGF阳性神经元明显减少 ,表达明显降低。　结论　心房后壁心内神经节存在NGF阳性神经元 ,并随年龄增加表达减少 ,提示NGF表达的减少可能与心脏功能的退化相关。Objective To study the existence and variance of nerve growth factor positive neurons in the intrinsic cardiac ganglia of adult (3 months) and old (15 months) rats. Method Immunohistochemical staining technique. Results NGF positive neurons exist in the intrinsic cardiac ganglia of the adult and old rats, but these neurons decreased remarkably and NGF expression reduced obviously in the cardiac ganglia of old rats.Conclusions The find of NGF positive neurons in the posterior wall of atria provides morphologic evidence for the normal existence and the decreasing of NGF related with age in the cardiac ganglia.It also indicates that the degeneration of heart function may correlate closely to the expression of NGF.

关 键 词：神经生长因子 大鼠 心内神经节 表达 免疫组织化学 

分 类 号：Q421[生物学—神经生物学]