雄激素对大鼠心内神经节神经生长因子表达的影响  

THE INFLUENCE OF ANDROGEN ON EXPRESSION OF NERVE GROWTH FACTOR IN INTRACARDIAC GANGLIA IN RATS

作　　者：刘晓柳[1] 李光千[2] 殷树仪[2] 赵小明[2] 范玉华[2] 

机构地区：[1]武汉科技大学医学院解剖学教研室,武汉430080 [2]华中科技大学同济医学院解剖学系,武汉430030

出　　处：《解剖学报》2004年第1期103-105,共3页Acta Anatomica Sinica

摘　　要：目的　观察神经生长因子 (NGF)在成年雄性大鼠、雌性大鼠、雌性大鼠睾酮处理组、睾丸切除大鼠、睾丸切除后睾酮替代大鼠心房后壁心内神经节的表达及变化。　方法　免疫组织化学染色。　结果　各组大鼠心内神经节均存在NGF阳性神经元 ,但睾丸切除组大鼠心内神经节NGF阳性神经元的数量明显减少 ,表达明显降低。　结论　心内神经节细胞内含NGF ;雄激素可能影响心内神经节细胞的NGF表达。Objective To study the expression and variance of nerve growth factor(NGF) immunoreactive (NGF-IR) neurons in the intracardiac ganglia,comparison was made among normal adult male and female rats,testosterone treated female rats,orchidectomized male rats and orchidectomized male rats that were treated with testosterone. Methods Immunohistochemical staining technique was used. Results NGF-IR neurons were presented in the intracardiac genglia of these groups,but the number of the NGF-IR neurons decreased remarkably and their expression reduced obviously in the intracardiac ganglia of orchidectomized rats.Conclusion NGF was presented in rat intracardiac ganglionic neurons and androgen might have the capacity regulating the expression of NGF in intracardiac ganglia.

关 键 词：雄激素 大鼠 心内神经节 神经生长因子 表达 免疫组织化学 

分 类 号：Q421[生物学—神经生物学] R322[生物学—生理学]