HCG分泌与类甲亢关系的临床研究  

The Study of Relationship between the Function of Thyroid and HCG in Early Pregnancy

作　　者：修霞[1] 郭永[1] 王清图[1] 陶华娟[1] 齐峰[1] 卢莉萍[1] 黄恩红[1] 

机构地区：[1]潍坊市妇幼保健院,山东潍坊261011

出　　处：《潍坊医学院学报》2004年第1期19-21,共3页Acta Academiae Medicinae Weifang

基　　金：潍坊市科技局资助课题 (课题编号 :1 999 1 1 )

摘　　要：目的　探讨妊娠早期HCG分泌与甲状腺功能的关系。方法　将 12 0例妊娠 6～ 12周孕妇分为单胎初产、单胎经产、双胎、妊娠剧吐四组 ,抽空腹肘静脉血 2ml采用酶联免疫吸附测定法观察T3 ,T4,TSH与HCG的关系及各组间HCG的定量关系。结果　单胎初产组 :T3 2 6 10 7± 1.2 8nmol L ,T416 0 .71± 4 8.16nmol L ,TSH 5 .14± 1.4 2nmol L ,HCG 4 997.5 0± 14 4 8.4 0nmol L ,单胎经产组 :T3 2 .4 8± 0 .6 1nmol L ,T416 0 .6 1± 5 0 .2 1nmol L ,TSH 5 .35± 1.4 0nmol L ,HCG 5 2 6 7.18± 10 84 .5 5nmol L ,双胎组 :T3 2 .10± 0 .6 6nmol L ,T416 8.11± 4 7.4 7nmol L ,TSH 4 .93± 1.4 2nmol L ,HCG 5 74 1.6 7± 1189.0 5nmol L ,妊娠剧吐组 :T3 2 .5 8± 1.5 3nmol L ,T4176 .2 5± 6 7.5 0nmol L ,TSH 4 .9179±0 .93nmol L ,HCG 6 0 35 .2 9± 12 6 4.85nmol L。结论　妊娠剧吐与双胎组中HCG与TSH呈相关性 ,双胎组HCG与T4有相关性 ,双胎与妊娠剧吐组HCG有差异。提示HCG对垂体 甲状腺轴有一定的调节作用。Objective To investigate the relationship between the function of thyroid and HCG in early pregnancy.Methods The ELISA was used to measure the serum concentration of T 3,T 4,TSH,HCG.To the 120 cases of pregnant women whose pregnant periods were 6～12 weeks.The 120 cases were divided into Four groups:singl fetal first labor,singl fetal second labor,twin pregnancy and hyperemesis gravidarum,to analyse and to compare the difference of HCG among four groups,T 3 and HCG,T 4 and HCG,TSH and HCG.Results Singl fetal first labor:T 3 2.61±1.28,T 4 160.71±48.16,TSH 5.14±1.42,HCG 4997.50±1448.40nmol/L;Singl fetal second labor:T 3 2.48±0.61,T 4 160.61±50.21,TSH 5.35±1.40,HCG 5267.18±1084.55nmol/L;twin pregnancy:T 3 2.10±0.66nmol/L,T 4.168.11±47.47nmol/L,TSH 4.93±1.42nmol/L,HCG 5741.67±1189.05nmol/L;Hyperemesis gravidarum:T 3 2.59±1.53,T 4 176.25±67.50,TSH 4.92±0.93nmol/L,HCG 6035.29±1264.85nmol/L.Conclusion A signficant negative correlation between TSH and HCG levels was demonstrated in hyperemesis gravidarum and twin pregnancy.A signficant correlation between T 4 and HCG levels was demonstrated in twin pregnancy.A signficant correlation between HCG levels was demonstrated in hyperemesis gravidarum and twin pregnancy.HCG may be as role of regulation of pituitary-thyroid ascis in early pregnanncy.

关 键 词：HCG T3 T4 TSH 妊娠剧吐 类甲亢 

分 类 号：R714.2[医药卫生—妇产科学]