常用抗精神病药物对心电图影响的相关分析  

Analysis of Usual Antipsychotics on Influences of Electrocardiogram

作　　者：张志彬[1] 刘玉厚[1] 李宜翠[1] 

机构地区：[1]山东省临沂市精神卫生中心,临沂276005

出　　处：《中国药师》2004年第5期377-379,共3页China Pharmacist

摘　　要：目的 :探讨常用抗精神病药物与ECG异常的关系。方法 :对符合要求的 870例住院精神病人用药后的ECG变化进行分析。结果 :ECG异常共 32 1例 ( 36 .9% ) ,各种药物所致ECG异常的发生率无明显差异 ,氯氮平、氯丙嗪对ECG的影响相对高于其它药物 ,但无统计学差异 ;≥ 4 0岁者较 <4 0岁者ECG异常的风险明显增高。结论 :常用抗精神病药物均可引起ECG异常 ,用药期间应注意定期检查ECG。Objective: To explore the relationship between the usual antipsychotics and influences of ECG. Method: The ECG of 870 inpatients were analyzed.Result: 321 inpatients occured the changes of ECG , the changes of ECG had no significant difference among antipsychotics( P > 0.05 ). The incidences of clozapine and chlorpromazine induced abnormalities of ECG were higher than the others, but no significant difference was found ( P > 0.05 ). The ≥40 years of patients were more than <40 years patients in the changes of ECG.Conclusion: The usual antipsychotics may cause the change of ECG. It is suggested that the ECG must be examined in the therapy of using antipsychotics.

关 键 词：抗精神病药物 ECG异常 

分 类 号：R971[医药卫生—药品] .41[医药卫生—药学]