4-氨基吡啶合成方法改进  

An Improved Synthesis of 4-Aminopyridine

作　　者：杨园园[1] 周国权[1] 陈新志[1] 

机构地区：[1]浙江大学材料与化工学院,杭州310027

出　　处：《应用化学》2004年第5期530-531,共2页Chinese Journal of Applied Chemistry

摘　　要：Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%～85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.Cyanopyridine was at first catalytically hydrolyzed to give isonicotinamide in the presence of Mg-Fe oxides with yield 92%. 4-Aminopyridine was obtained from isonicotinamide in yield of 83%～85% by Hofmann reaction using iodo-benzene as catalyst. All of the reaction were monitored by TLC and the products were confirmed by IR, NMR and melting point determination.

关 键 词：甲酰胺基吡啶 氨基吡啶 Hofmann降解 水解 

分 类 号：O621[理学—有机化学]