预防性抗菌治疗对重型病毒性肝炎患者自发性细菌性腹膜炎的影响  

Effect of Preventive Antibacterial Treatment on Spontaneous Bacterial Peritonitis in Patients with Severe Hepatitis

作　　者：任星峰[1] 葛娅[1] 李敬安[1] 靳桂明[2] 杨群[1] 赵甫涛[1] 胡泰洪[1] 

机构地区：[1]广州军区武汉总医院传染科,湖北武汉430070 [2]广州军区武汉总医院感染控制科

出　　处：《中国医师杂志》2004年第4期489-490,共2页Journal of Chinese Physician

摘　　要：目的　探讨预防性抗菌治疗对重型病毒性肝炎患者自发性细菌性腹膜炎 (SBP)的发生及疗效的影响。方法　 12 0例重型病毒性肝炎患者随机分成 2组 ,治疗组 62例 ,入院后在综合护肝治疗的基础上 ,给予预防性抗菌治疗 ;对照组 5 8例 ,入院后仅给予综合护肝治疗。对两组患者SBP发生率、平均住院天数、存活率进行对比分析。结果　SBP的发生率治疗组 2 7 4% ( 17/62 ) ,对照组 44 8% ( 2 6/5 8) ,( χ2 =3 95 ,P <0 0 5 )。治疗组住院天数 ( 5 6 3± 2 4 2 )d ,对照组 ( 69 1± 2 6 1)d(t =2 79,P <0 0 1)。治疗组存活率 43 5 % ( 2 7/62 ) ,对照组 2 5 9% ( 15 /5 8) ( χ2 =4 12 ,P <0 0 5 )。结论　预防性抗感染治疗可降低重型病毒性肝炎SBP的发生率 ,缩短住院天数 ,提高存活率。Objective To explore the effect of preventive antibacterial treatment on spontaneous bacterial peritonitis (SBP) in the patients with severe hepatitis. Methods 120 cases of the patients with severe hepatitis were divided into two groups randomly. The patients in group A (n=62) received preventive antibacterial treatment except therapy for protecting liver. The patients in group B (n=58) only received therapy for protecting liver and served as control. Results In the group A and group B, the SBP frequency was 27.4% (17/62) and 44.8%(26/58) respectively (χ 2=3.95,P<0.05), the hospitalized days were 56.3±24.2 and 69.1±26.1 respectively(t=2.79,P<0.01), and the survival rate was 43.5%(27/62) and 25.9%(15/58) respectively(χ 2=4.12,P<0.05). Conclusion Preventive antibacterial treatment may reduce the SBP frequency and the hospitalized days, and increase the survival rate in the patients with severe hepatitis.

关 键 词：病毒性肝炎 自发性细菌性腹膜炎 抗菌治疗 预防措施 抗菌药 SBP 

分 类 号：R512.6[医药卫生—内科学]