“以痛为腧”按揉法对神经痛大鼠的镇痛作用  

Analgesic Effect of Tender Point Kneading on Neuralgia in Rats

作　　者：李征宇[1] 陈培青[1] 严隽陶[1] 刘骁[2] 杨香媛[2] 吴根诚[3] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院,200437 [2]复旦大学药学院,200032 [3]复旦大学上海医学院,200032

出　　处：《上海中医药杂志》2004年第5期54-56,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：为探索“以痛为腧”按揉法的镇痛作用及其机理 ,采用结扎大鼠坐骨神经干的方法制作神经痛大鼠模型 ,从术后第 7天开始在神经结扎处以按揉法治疗 ,每天 1次 ,共 2 1d。并以光热测痛法测定大鼠的痛敏分数 ;2 1d后采用放免法测定其血 β 内啡肽含量。结果 :单次治疗 2 0min后 ,大鼠痛敏分数显著下降 ,并可持续 90min ,与对照组相比具有统计学意义 (P <0 0 1) ;多次推拿次日测痛显示 ,随着推拿次数的增加 ,大鼠痛敏分数绝对值逐渐减小 ,与对照组相比均有显著性差异(P <0 0 5 )。另外 ,血浆 β 内啡肽含量明显高于对照组 ,P <0 0 1。提示“以痛为腧”按揉法治疗 ,具有较明显的即刻镇痛和疗程镇痛的作用 ;其机理可能与其能提高 β 内啡肽含量有关。To observe the analgesic effect and its mechanism of tender point kneading, rats' sciatic trunks were ligated. From the seventh day after ligation, the ligation points were kneaded once a day for total 21 days. During the kneading, the scores of pain measurement were detected; and the β-endorphin was assayed on the 21st day. Results: Twenty minutes after single treatment, the scores reduced obviously and remained for 90 minutes, with significant difference in comparison with control group (P<0.01); after a few treatments, the higher kneading frequency is, the lower scores were, with marked difference in comparison with control group (P<0.05). Moreover, theβ-endorphin were obviously higher in treatment group than in control group (P<0.01). It is suggested that tender point kneading has remarkable analgesic effect possibly by increasing the concentration ofβ-endorphin.

关 键 词：神经痛 大鼠模型 “以痛为腧” 按揉法 痛敏分数 血浆Β-内啡肽 

分 类 号：R244.1[医药卫生—针灸推拿学]