环肽Ascidiacyclamide异构体的合成  

Synthesis of the Isomer of Cyclopeptide Ascidiacyclamide

作　　者：简志刚[1] 蹇敦龙[1] 龙康侯[1] 

机构地区：[1]中山大学化学系

出　　处：《中山大学学报（自然科学版）》1992年第2期57-61,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

摘　　要：从缬氨酸,L-丝氨酸,L-苏氨酸,L-异亮氨酸出发合成了海洋环肽Ascidiacy-clamide的异构体cyclo-[-D,L-(Val)Thz-L-Ser-L-Ile-D,L-(Val)Thz-L-Thr-L-Ile-]-。其中噻唑氨基酸由Hantzsch方法合成,肽链由DCC-HOBT(DCC即二环己基碳化二亚胺,dicyclohexylcarbodimide;HOBT即1-羟基合水苯并噻唑,1-hydroxybenzotria-zolenydrate)缩合而形成。关大环采用叠氮方法。The cyclopeptide DL-(Val)T hz-L-Ser-L-Ile L-Ile-L-Thr-DL-(ValThz,an isomer of marine cyclopeptide Ascidiacyclamide has been synthesized. The rhiazole amino acid was prepared by Hantzsch method. The peptide bonds were constructed by DCC-HOBT coupling method and the peptide ring was formed by azide method.

关 键 词：肽类 异构体 海洋 抗肿瘤活性 

分 类 号：TQ464.7[化学工程—制药化工]