BAI型国产覆膜支架治疗犬主动脉假性动脉瘤  

Stent-graft in the treatment of canine model of aortic pseudo-aneurysm

作　　者：许尚栋[1] 张兆光[1] 杜嘉会[1] 孙衍庆[1] 寇亚明[1] 曹凤荣[1] 

机构地区：[1]北京市心肺血管疾病研究所北京首都医科大学附属北京安贞医院心外科,100029

出　　处：《中华实验外科杂志》2004年第1期41-42,共2页Chinese Journal of Experimental Surgery

基　　金：国家重点科技攻关项目 (96 90 7 0 1 0 1 )

摘　　要：目的　探讨BAI型国产覆膜支架治疗动物主动脉假性动脉瘤的可行性和有效性。方法　在 16条犬中建立腹主动脉假性动脉瘤模型 ,分为 4组 ,各 4只 ,1组为对照组 ,其余 3组为实验组。实验组 2周后行国产镍钛记忆合金覆膜支架 (BAI型 )植入术。分别于术后第 2、3、6个月时处死动物 ,处死前做CT及动脉造影。病理检查包括光镜与电镜。结果　国产覆膜支架 (BAI型 )均成功地将动脉瘤封闭 ,成功率为 10 0 %。术后死亡率为 0。覆膜支架无移位 ,无内漏。 2例出现支架内血栓栓塞 ,栓塞率 17%。其余病理检查示管腔通畅 ,覆膜内表面均已内皮化。 7条犬的腰动脉再通。结论　国产覆膜支架 (BAI型 )在犬的腹主动脉假性动脉瘤模型的治疗中是可行、有效的。Objective To test the feasibility and effectiveness of stent-graft (type BAI) in the treatment of canine abdominal pseudo-aneurysm model.Methods Using vascular graft,16 canine models of abdominal aortic pseudo-aneurysm were set up.The dogs were equally divided into 4 groups:Group 1 was control group;The remaining three groups received stent-graft treatment and were sacrificed at 2,3 and 6 months respectively after stent-graft implantation.Self-expandable stent covered with a thin Dacron jacket (type BAI) was used to exclude the aneurysm.Before the dogs were put to death mercifully,CT and aortography were done.After death,pathological examinations including light microscopic and electron microscopic scanning were done.Results All aneurysms were excluded successfully.No death occurred after the stent-graft implantation.No displacement or endoleak occurred.Two stent-grafts were totally occluded with thrombosis.Other stent-grafts were patent and the luminal surfaces were covered by neointima.Conclusion Dacron covered stent-graft (type BAI) was feasible and effective in the treatment of the canine model of abdominal aortic pseudo-aneurysm.

关 键 词：BAI型国产覆膜支架 治疗 主动脉假性动脉瘤 腹主动脉假性动脉瘤模型 

分 类 号：R543.1[医药卫生—心血管疾病]