人类白细胞抗原-DR基因与不明原因的重复性流产的关联性研究  

Correlation of HLA-DR gene and unexplained recurrent spontaneous abortion

作　　者：李晓梅[1] 许燕雪[1] 晁岚[1] 于红玲[1] 闫旻[1] 杜丽娟[1] 

机构地区：[1]山东大学齐鲁医院妇产科,山东济南250012

出　　处：《山东大学学报（医学版）》2004年第2期162-164,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:探讨不明原因重复性自然流产(URSA)及其临床表现与人类白细胞抗原(HLA)DR1、DR3、DR4、DR10等位基因频率的关系。方法:运用聚合酶链反应-序列特异性引物(PCR-SSP)方法测定HLA-DR1、DR3、DR4、DR10的基因频率。结果:HLA-DR1、DR3的阳性率在URSA组与对照组差异无显著性,DR4阳性率在URSA组明显高于对照组,差异有显著性,DR10阳性率在URSA组高于对照组,但差异无显著性。DR4基国分布与URSA患者的不同临床特征无明显关联,与抗心磷脂抗体(ACA)有较强关联。结论:HLA-DR4与URSA有明显关联,尤其在ACA(+)患者中关联更强。Objective:To study the correlationship between HLA-DR genetypes and unex- plained recurrent spontaneous abortion(URSA).Methods:HLA-DR genetypes were detected by the technique of polymerase chain reaction-specific sequence primer(PCR-SSP).Results:The frequency of HLA-DR1 and DR3 gene in URSA had no significant difference between URSA patients and the con- trol group.HLA-DR4 frequency was significantly higher in patients than in control group.HLA-DR10 frequency in patients was higher than that in control group,but had no significant difference.HLA- DR4 was related to anticardiolipin antibody(AC)in URSA.HLA-DR4 hadn’t any significant difference in age,area,period,and type.Conclusion:HLA-DR4 is correlated with URSA especially in ACA (+)patients.

关 键 词：流产 习惯性 人类白细胞抗原 抗心磷脂抗体 

分 类 号：R714.21[医药卫生—妇产科学]