奥昔布宁凝胶剂的制备和体外释药特性  

Preparation and the specific delivery of oxybutynin transcutaneous gel in vitro

作　　者：温清[1] 郭瑞臣[2] 温绪东 王本杰[2] 

机构地区：[1]济南市中心医院药剂科,山东济南250013 [2]山东大学齐鲁医院临床药理研究所,山东济南250012 [3]山东省皮肤病防治研究所,山东济南250022

出　　处：《山东大学学报（医学版）》2004年第2期235-237,共3页Journal of Shandong University:Health Sciences

摘　　要：目的:制备奥昔布宁凝胶剂,评价其体外释药性能。方法:以氮酮为促透剂,以羟丙甲基纤维素为凝胶基质,正交法设计处方,用扩散池进行奥昔布宁凝胶剂12h的经皮扩散试验,高效液相色谱法测定药物累计释放浓度,用时间滞留法求算经皮渗透参数。结果:奥昔布宁凝胶剂经度扩散参数分别为T_(lag)3.3h,D7.95E-07cm^2.h^(-1),Km20.91,Jss2.11E-04mmol.cm^(-2).h^(-1),12h体外累计释放量为(11.11±0.96)％。结论:奥昔布宁凝胶剂透过率高,渗透性好。Objective:To prepare oxybutynin transcutaneous gel and evaluate its release speci- fity in vitro.Methods:Azone was used as promoted agent and HPMC as base for oxybutynin gel. Transcutaneous permeation in 12h was studied in vitro.The concentrations of oxybutynin in medium were determined by HPLC method.The diffusion coefficient(D),partition coefficient(Km)and steadstate flux(Jss)were calculated with the lag time method.Results:Transcutaneous diffusive parameters of oxy- butynin gel were as follows:T_(lag)(3.3h),D(7.95E-07cm^2.h^(-1)),Km(20.91),Jss(2.11E-04 mmol.cm^(-2).h^(-1)),and the accumulative release of oxybutynin gel was([11.11±0.96)%.Conclusion:Oxybutynin transcutaneous gel has a well release characteristic.

关 键 词：奥昔布宁 凝胶剂 经皮扩散 滞留时间法 高效液相色谱法 

分 类 号：R944[医药卫生—药剂学]